| All Quarterbacks vs Bills | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Team | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Texans QB vs Bills [+] | 38 | 26 | 274 | 2 | 0 | 106.7 | 2 | 15 | 7.50 | 0 | 2 | 19 |
| 2 | Lions QB vs Bills [+] | 38 | 26 | 327 | 4 | 0 | 130.0 | 3 | 7 | 2.33 | 0 | 0 | 37 |
| 3 | Chargers QB vs Bills [+] | 34 | 20 | 226 | 1 | 1 | 76.3 | 4 | 17 | 4.25 | 0 | 0 | 14 |
| 4 | Patriots QB vs Bills [+] | 37 | 22 | 269 | 3 | 1 | 97.7 | 8 | 54 | 6.75 | 0 | 1 | 31 |
| 5 | Rams QB vs Bills [+] | 54 | 40 | 383 | 3 | 0 | 111.9 | 0 | 0 | 0 | 0 | 0 | 33 |
| 6 | Raiders QB vs Bills [+] | 41 | 23 | 313 | 2 | 1 | 86.7 | 0 | 0 | 0 | 0 | 0 | 22 |
| Average | 40.33 | 26.17 | 298.67 | 2.50 | 0.50 | 102.50 | 2.83 | 15.50 | 5.47 | 0.00 | 0.50 | 25.33 | |
| Season | All Quarterbacks vs Bills | 242 | 157 | 1792 | 15 | 3 | 102.5 | 17 | 93 | 5.47 | 0 | 3 | 156 |