| All Quarterbacks vs 49ers | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Team | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Rams QB vs 49ers [+] | 28 | 17 | 168 | 0 | 1 | 62.8 | 3 | 8 | 2.67 | 0 | 0 | 4 |
| 2 | Dolphins QB vs 49ers [+] | 23 | 14 | 197 | 1 | 0 | 103.0 | 2 | 6 | 3.00 | 0 | 0 | 13 |
| 3 | Cardinals QB vs 49ers [+] | 52 | 38 | 280 | 2 | 0 | 98.2 | 4 | 4 | 1.00 | 1 | 0 | 29 |
| 4 | Broncos QB vs 49ers [+] | 42 | 25 | 214 | 1 | 0 | 80.9 | 2 | 10 | 5.00 | 0 | 0 | 15 |
| 5 | Seahawks QB vs 49ers [+] | 29 | 18 | 195 | 1 | 2 | 64.6 | 1 | 5 | 5.00 | 0 | 0 | 9 |
| 6 | Commanders QB vs 49ers [+] | 40 | 29 | 300 | 2 | 0 | 110.4 | 4 | 10 | 2.50 | 0 | 0 | 25 |
| 7 | Falcons QB vs 49ers [+] | 34 | 25 | 213 | 3 | 0 | 118.9 | 5 | -1 | -0.20 | 0 | 0 | 26 |
| 9 | Raiders QB vs 49ers [+] | 32 | 22 | 216 | 1 | 3 | 58.9 | 2 | 0 | 0.00 | 1 | 0 | 14 |
| Average | 35.00 | 23.50 | 222.88 | 1.38 | 0.75 | 88.70 | 2.88 | 5.25 | 1.83 | 0.25 | 0.00 | 16.25 | |
| Season | All Quarterbacks vs 49ers | 280 | 188 | 1783 | 11 | 6 | 88.7 | 23 | 42 | 1.83 | 2 | 0 | 135 |