| All Running Backs vs Bills | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Team | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Texans RB vs Bills [+] | 29 | 102 | 3.52 | 2 | 4 | 4 | 17 | 4.25 | 1 | 0 | 29 |
| 2 | Lions RB vs Bills [+] | 17 | 59 | 3.47 | 0 | 9 | 7 | 74 | 10.57 | 1 | 0 | 18 |
| 3 | Chargers RB vs Bills [+] | 24 | 114 | 4.75 | 0 | 11 | 7 | 44 | 6.29 | 1 | 0 | 21 |
| 4 | Patriots RB vs Bills [+] | 27 | 89 | 3.30 | 1 | 7 | 3 | 27 | 9.00 | 0 | 0 | 18 |
| 5 | Rams RB vs Bills [+] | 21 | 68 | 3.24 | 2 | 12 | 9 | 80 | 8.89 | 0 | 0 | 26 |
| 6 | Raiders RB vs Bills [+] | 20 | 65 | 3.25 | 1 | 8 | 6 | 42 | 7.00 | 0 | 0 | 16 |
| 8 | Ravens RB vs Bills [+] | 16 | 73 | 4.56 | 1 | 10 | 6 | 27 | 4.50 | 0 | 0 | 15 |
| 9 | Vikings RB vs Bills [+] | 11 | 51 | 4.64 | 0 | 5 | 4 | 14 | 3.50 | 0 | 0 | 6 |
| Average | 20.62 | 77.62 | 3.76 | 0.88 | 8.25 | 5.75 | 40.62 | 7.07 | 0.38 | 0.00 | 18.75 | |
| Season | All Running Backs vs Bills | 165 | 621 | 3.76 | 7 | 66 | 46 | 325 | 7.07 | 3 | 0 | 149 |