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The PGA Tour stays in the Sunshine State this week for the 2022 Players Championship. The tournament tees off on Thursday, March 8 at the TPC Sawgrass Stadium Course in Ponte Vedra Beach, Fla., and will feature 47 of the top 50 golfers in the Official World Golf Rankings. World No. 1 Jon Rahm, No. 2 Collin Morikawa, and No. 8 Justin Thomas are the 14-1 betting favorites in the latest Players Championship odds from Caesars Sportsbook. The Players Championship field also includes big-names such as Rory McIlroy (18-1),  Dustin Johnson (30-1), and Brooks Koepka (35-1). With a field this talented, there will be several intriguing head-to-head matchups this week at TPC Sawgrass. 

Head-to-head golf betting is growing in popularity and allows fans to bet on single round or full tournament golfer vs. golfer matchups. Before locking in your own 2022 Players Championship head-to-head bets, be sure to check out the golf predictions and betting advice from SportsLine DFS pro and PGA expert, Mike McClure. 

SportsLine's proprietary model, built by McClure, has been red-hot since the PGA Tour resumed play in June of 2020. In fact, the model is up over $9,000 on its best bets since the restart, nailing tournament after tournament.

At the 2021 Open Championship, McClure's best bets included Collin Morikawa winning outright even though he was listed as a massive 40-1 long shot. In addition, McClure's model was all over Jon Rahm's (10-1) first career major championship victory at the 2021 U.S. Open. Rahm was two strokes off the lead heading into the weekend, but the model still projected him as the winner.

At the Sony Open in 2022, McClure's model listed Hideki Matsuyama among the top contenders. The reigning Masters champion went out and overcame a five-stroke deficit on the back nine of the final round to notch his eighth career PGA Tour victory.

This same model has also nailed a whopping seven majors entering the weekend. Anyone who has followed it has seen massive returns.

Now, McClure has dialed in on the 2022 Players Championship golf tournament, and just locked in his head-to-head picks and PGA predictions. You can only see McClure's Players Championship head-to-head golf picks at SportsLine.

Top 2022 Players Championship head-to-head predictions 

One head-to-head matchup McClure loves this week is Patrick Cantlay (-110) over Rory McIlroy. Cantlay, ranked No. 4 in the Official World Golf rankings, has been on a fire in 2022, notching top-10 finishes in four of his five tournaments, and top-5 finished three times. His most recent outing at The Genesis Invitational resulted in a T-33, but prior to that at the Waste Management Phoenix Open he finished in sole possession of second place.

McIlroy may be a past Players Championship winner, but McClure will be leaning on Cantlay's recent form and well-rounded game when constructing his head-to-head bets for the 2022 Players Championship.

How to make 2022 Players Championship head-to-head picks

McClure is also targeting two other head-to-head bets featuring prominent PGA Tour stars, who both have the potential to be in contention on Sunday this week at TPC Sawgrass. Anyone who backs these picks could hit it big. You can only see McClure's expert predictions and analysis at SportsLine.

So what are the top head-to-head golf matchup picks for the 2022 Players Championship? And matchups offer huge betting value? Visit SportsLine now to see the top Players Championship head-to-head picks, all from the model that's nailed seven golf majors and won McClure over $2 million in DFS, and find out.