Saturday's UFC 264 main event lightweight bout between Dustin Poirier and Conor McGregor is fast approaching and bettors are gearing up with an eye toward the many available UFC 264 prop bets. This will be the third time the legendary fighters have met. McGregor won the first meeting by TKO at UFC 178 in September 2014, while Poirier returned the favor this past January at UFC 257. The main UFC 264 fight card from Las Vegas will begin at approximately 10 p.m. ET.

Among the more popular Dustin Poirier vs. Conor McGregor props from William Hill Sportsbook involve whether the fight will go the distance at +275 (risk $100 to win $275), and whether McGregor will win by TKO at +138. There is also a UFC 264 prop bet on the welterweight bout between Gilbert Burns and Stephen Thompson and whether or not it will be won by decision. Before making any UFC 264 prop bet picks or UFC 264 predictions of your own, make sure to see what SportsLine MMA expert Brandon Wise has to say.

Wise specializes in picking main-card fights for UFC, which has enabled him to be profitable every year. In fact, Wise called Israel Adesanya by decision at +140 and Brandon Moreno to win outright at +190 at UFC 263 last month. Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249.

He also nailed Khabib Nurmagomedov's destruction of Conor McGregor in 2018, Stipe Miocic's defeat of Daniel Cormier, Max Holloway's downfall in 2019 and Justin Gaethje's TKO victory over Tony Ferguson in May of last year. Now, with UFC 264: Poirier vs. McGregor 3 fast approaching, Wise has carefully studied every main-card matchup and the available props and released his MMA predictions. You can only see them here.

Dustin Poirier vs. Conor McGregor expert preview

Wise believes this could be the most important fight of McGregor's career. Wise wants to see what adjustments McGregor makes after his TKO loss to Poirier in January. McGregor has lost two of his last three fights, with the only victory coming at UFC 246 in January 2020. In that bout, McGregor knocked out Donald Cerrone at the 40-second mark of the first round.

McGregor has strong boxing skills and of his 22 career victories, 19 have been by knockout. He is a former UFC featherweight and lightweight double-champion and is fifth in the UFC lightweight rankings. McGregor began his career in March 2008 and has had only one bout go five rounds. In 2015, he set a UFC record by recording the fastest knockout in the organization's history in 13 seconds in a TKO win over Jose Aldo. 

Poirier is No. 1 in the UFC lightweight rankings and rated No. 6 in the UFC men's pound-for-pound rankings. Poirier has been on a roll of late, winning six of his last seven bouts, with the only loss coming at UFC 242 in Sept 2019. In that match, he lost by submission to Khabib Nurmagomedov in 2:06 of the third round. The bout was for the UFC lightweight championship. 

Poirier rebounded by winning a major decision over Dan Hooker on June 27, 2020. He followed that up by knocking out McGregor at the 2:32 mark of the second round in the Performance of the Night. You can only see who Wise is backing and get his strong 7-1 UFC 264 parlay on SportsLine.

Top UFC 264: McGregor vs. Poirier predictions

One of the Poirier vs. McGregor 3 prop bets the expert recommends on the UFC 264 card: Thompson will defeat Burns via decision. Thompson had dropped two consecutive bouts, a decision to Darren Till on May 27, 2018, and a TKO to Anthony Pettis on March 23, 2019, before rebounding with a unanimous decision victory over Vicente Luque at UFC 244 in November 2019. 

Burns, who had won six bouts in a row, lost by TKO in February to Kamaru Usman at UFC 258. The bout was for the UFC welterweight championship. Prior to that, Burns had the Performance of the Night in his two previous matches, including a victory by unanimous decision over Tyron Woodley in May 2020.

How to make Dustin Poirier vs. Conor McGregor prop bets

Wise is also backing an underdog to pull off an upset, rewarding anyone who backs him. You can only see which fighters to back here.

Who wins Dustin Poirier vs. Conor McGregor at UFC 264? And which prop bets should you back for a 7-1 payout? Visit SportsLine now to see the top UFC 264 predictions and picks, all from the expert who has been profitable every year.

UFC 264 fight card, odds

Dustin Poirier (-130) vs. Conor McGregor (+110)  
Stephen Thompson (-140) vs. Gilbert Burns (+120)  
Tai Tuivasa (-140) vs. Greg Hardy (+120)  
Irene Aldana (-145) vs. Yana Kunitskaya (+125)  
Sean O'Malley (-800) vs. Kris Moutinho (+550)  
Max Griffin (-175) vs. Carlos Condit (+155)  
Michel Pereira (-160) vs. Niko Price (+140)  
Trevin Giles (-120) vs. Dricus du Plessis (+100)  
Ilia Topuria (-240) vs. Ryan Hall (+200)  
Jennifer Maia (-190) vs. Jessica Eye (+170)  
Brad Tavares (-175) vs. Omari Akhmedov (+155)  
Zhalgas Zhumagulov (-400) vs. Jerome Rivera (+320)  
Alen Amedovski (-175) vs. Yaozong Hu (+155)