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An NFC clash in the divisional round of the 2024 NFL playoffs will take place Saturday when the top-seeded San Francisco 49ers host the No. 7 seed Green Bay Packers. San Francisco (12-5) earned the only bye in the conference after winning its second straight NFC West title and 22nd overall. The 49ers lost four of their first five postseason meetings with the Packers but have won the last four, including a 13-10 triumph in the divisional round two years ago. Green Bay (10-8) has won four straight contests and seven of its last nine after stunning Dallas 48-32 in the wild-card round.

Kickoff from Levi's Stadium is set for 8:15 p.m. ET. San Francisco is a 10-point favorite in the latest 49ers vs. Packers odds from the SportsLine consensus, while the over/under for total points scored is 50.5. Before locking in any Packers vs. 49ers picks, you need to see the latest NFL predictions from SportsLine's proven projection model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the divisional round of the 2024 NFL playoffs on an incredible 183-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 37-21 roll on top-rated picks since Week 7 of last season and nailed seven straight top-rated picks entering the 2024 NFL playoffs.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has zeroed in on 49ers vs. Packers and just revealed its picks and predictions. You can see the model's picks only at SportsLine. Here are several NFL odds and betting lines for Packers vs. 49ers:

  • 49ers vs. Packers spread: San Francisco -10
  • 49ers vs. Packers over/under: 50.5 points
  • 49ers vs. Packers money line: San Francisco -471, Green Bay +359
  • SF: 49ers were 3-5 against the spread as home favorites in the regular season
  • GB: Packers are 5-3 ATS as road underdogs this campaign
  • 49ers vs. Packers picks: See picks here
  • 49ers vs. Packers live stream: fubo (try for free)

Why the 49ers can cover

San Francisco possesses one of the top offensive trios in the NFL in quarterback Brock Purdy, running back Christian McCaffrey and wide receiver Deebo Samuel. Including the playoffs, the 49ers are 18-1 with averages of 32.7 points and plus-16.0 differential per game when the three stars are healthy. This season, they ranked second in the league in total offense (398.4 yards) and became the first team since the 2004 Indianapolis Colts to boast a 4,000-yard passer and four players with 1,000 scrimmage yards.

Purdy, who was the last selection in the 2022 NFL Draft, finished fifth in the league with a team-record 4,280 passing yards and ranked third with 31 touchdown passes while setting the NFL mark for yards per attempt (9.6) in a single season. McCaffrey gained a career-high 1,459 yards on the ground to win the league rushing title and tied Miami's Raheem Mostert for most total touchdowns with 21, including seven through the air. He shared first place on the club in that category with wideout Brandon Aiyuk and Samuel, who racked up 892 receiving yards while also running for 225 and five TDs. See which team to pick here.

Why the Packers can cover

Jordan Love looked nothing like a young quarterback making his postseason debut last week as he carved up Dallas' secondary, completing 16-of-21 pass attempts for 272 yards and three touchdowns. The 25-year-old has been nearly mistake-free while leading Green Bay to wins in seven of its last nine games as he has thrown 21 TD passes and just one interception. Love has connected with nine different players for scores during the run, hooking up with wideouts Jayden Reed, Dontayvion Wicks and Christian Watson four times apiece.

Reed was the Packers' leader during his rookie season with 793 receiving yards and tied Romeo Doubs for first on the team with eight touchdown catches. Doubs set a career high with 151 yards against the Cowboys while Aaron Jones led Green Bay's ground attack with 118 yards and three TDs. The 29-year-old running back, who ran for only two scores in the regular season, tied the NFL playoff records for most rushing touchdowns in a road game and a wild-card contest. Jones has averaged 99.5 scrimmage yards in six career postseason games while recording eight total TDs, including a team-record seven on the ground. See which team to pick here.

How to make 49ers vs. Packers picks

SportsLine's model is leaning Under the point total, predicting 46 total points. The model also says one side of the spread has all the value. You can see the model's NFL picks and analysis only at SportsLine

So who wins 49ers vs. Packers, and which side of the spread has all the value? Visit SportsLine now to see which side of the Packers vs. 49ers spread you should jump on, all from the advanced model on a 183-129 roll on NFL picks, and find out.