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The Buffalo Bills will host the Denver Broncos on Monday Night Football to close out NFL Week 10. The Bills (5-4) have made the postseason four straight years, but they come into the Week 10 NFL matchup at Highmark Stadium with three losses in their past five games. Meanwhile, the Broncos (3-5) have won consecutive games and come in off their bye week. The Bills played on Sunday Night Football in Week 9, losing 24-18 to the Bengals. Denver upset Kansas City 24-9 in an AFC West showdown before their week off.

Kickoff is scheduled for 8:15 p.m. ET. Buffalo is a 7.5-point favorite in the latest Bills vs. Broncos odds while the over/under for total points scored is 47.5. Before you make any Broncos vs. Bills picks, you need to see the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2023 NFL season on an incredible 174-123 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 28-15 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has zeroed in on Bills vs. Broncos and just revealed its picks and predictions. You can visit SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Broncos vs. Bills:

  • Bills vs. Broncos spread: Buffalo -7.5
  • Bills vs. Broncos over/under: 47.5 points
  • Bills vs. Broncos money line: Buffalo -325, Denver +254
  • BUF: WR Stefon Diggs leads the league in receptions (70)
  • DEN: QB Russell Wilson ranks fifth in the NFL in passer rating (101.7)
  • Bills vs. Broncos: See picks here
  • Bills vs. Broncos live stream: fubo (try for free)

Why the Bills can cover

Buffalo's Josh Allen has played much better at home than on the road this season. The dual-threat quarterback is completing 67.2% of his passes and has 11 touchdown passes versus seven interceptions in five games away from Buffalo this season. The Bills are 1-4 in those contests. In four home games, he is completing 77.3% of his passes and has 13 touchdown passes against just two interceptions. Buffalo is 4-0 in those games.

In addition, the Bills have a prolific wideout in Stefon Diggs. The former All-Pro receiver already ranks fifth in franchise history in receiving yards (5,023) despite playing just 58 games with Buffalo. Only Andre Reed (13,095 yards), Eric Moulds (9,096), Lee Evans (5,934) and Elbert Dubenion (5,294) have more. See which team to pick here.

Why the Broncos can cover

Denver will be rested, while the Bills come in off an emotional matchup with a fellow AFC contender. The Broncos are 4-1 against the spread in their past five games after a bye week and have covered in their past two games after starting the season 0-5-1 ATS. Quarterback Russell Wilson has been managing the offense better this season, throwing just four interceptions and ranking fifth in the NFL in passer rating. He has thrown 16 touchdown passes, six to receiver Courtland Sutton.

Sutton and Jerry Jeudy have combined for 60 catches and 716 yards. Javonte Williams has rushed for at least 80 yards in consecutive games and Jaleel McClaughlin is averaging 7.1 yards on 38 carries. The Broncos had five takeaways against Chiefs and the once-struggling defense has allowed just 45 points over the past three games. Baron Browning has two sacks in two games since his return from injury, while Nik Bonitto and Jonathan Cooper have combined for 10. See which team to pick here.

How to make Bills vs. Broncos picks

SportsLine's model is leaning Over on the point total, predicting 48 total points. The model also says one side of the spread hits in almost 60% of simulations. You can see the model's NFL picks and analysis only at SportsLine

So who wins Broncos vs. Bills on Monday Night Football and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the Broncos vs. Bills spread you should jump on, all from the advanced model that is up well over $7,000 on top-rated NFL picks, and find out.