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The Denver Broncos and Detroit Lions will square off Saturday in an NFL Week 15 matchup at Ford Field. The Lions (9-4) lead the NFC North by two games, but are trying to pull out of a brief slide. They have lost two of their past three games, including a 28-13 setback to the divisional-rival Bears last Sunday. The Broncos are one of six AFC teams with 7-6 records and in the midst of an impressive 6-1 run. They cruised past the AFC West-rival Chargers 24-7 last Sunday and have won the past three meetings with the Lions. The most recent was a 38-10 victory in Denver in 2021.

Kickoff is set for 8:15 p.m. ET in Detroit. The Lions are five-point favorites in the latest Broncos vs. Lions odds on the SportsLine consensus, while the over/under for total points scored is 49. Before you make any Lions vs. Broncos picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2023 NFL season on an incredible 176-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 30-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Broncos vs. Lions 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Lions vs. Broncos:

  • Broncos vs. Lions spread: Detroit -5
  • Broncos vs. Lions over/under: 49 points
  • Broncos vs. Lions money line: Denver +190, Detroit -235
  • DEN: Broncos are 9-6 against the spread in their past 15 games as underdogs
  • DET: Lions are 10-5 ATS at home since the start of last season
  • Broncos vs. Lions picks: See picks at SportsLine

Why the Lions can cover

Detroit is seeking its first 10-victory season since 2014 and Dan Campbell has changed the culture since taking over in 2021. The Lions are 16-7 against the spread at home under the coach, the second-best home ATS record over that span. The offense is loaded with talent, with Jared Goff (3,449 yards, 21 TDs) leading the charge. The unit ranks in the top 10 in both rushing and passing, averaging 390 yards per game (third in the NFL) and 6.0 per play (fourth).

The Broncos have the third-worst defense (377.4 yards per game) and worst against the run (144). Detroit has a strong running back duo in David Montgomery (10 TDs) and Jahmyr Gibbs, who is third in the NFL in yards from scrimmage (980). Goff's main targets are wide receiver Amon-Ra St. Brown (1,063 yards, six TDs) and rookie tight end Sam LaPorta (702 yards, six TDs). On defense, Aidan Hutchinson is third in the NFL in QB pressures (76) and has 6.5 sacks. See who to back at SportsLine.

Why the Broncos can cover

Denver is 5-2 against the spread over its past seven games. The Broncos are plus-11 in turnover differential during their 6-1 run, while Detroit is minus-8 over the same span. Denver has allowed just 15.6 points per game since Week 7, while the Lions have given up 28.6. Russell Wilson has been avoiding mistakes, throwing zero interceptions in five of the past seven games, while Jared Goff has turned the ball over nine times since Week 8.

Wilson is completing 67.2% of his throws, passing for 2,662 yards and 23 touchdowns in 2023. Wideout Courtland Sutton has been on fire, catching a TD pass in seven of the past eight games. Slot receiver Jerry Jeudy and running back Samaje Perine have combined for 82 catches. Denver is tied for the NFL lead in takeaways (24), forcing 19 fumbles and recovering 13. Linebacker Alex Singleton has recovered two and ranks third in the NFL with 136 tackles. See who to back at SportsLine.

How to make Broncos vs. Lions picks

SportsLine's model is leaning Under the total, projecting 47 combined points. The model also says one side of the spread cashes in over 50% of simulations. You can only see the model's NFL picks and analysis at SportsLine

So who wins Broncos vs. Lions on Saturday in NFL Week 15, and which side of the spread cashes in over 50% of simulations? Visit SportsLine now to see which side of the Lions vs. Broncos spread to back, all from the model on a 176-129 roll on top-rated NFL picks, and find out.