Aaron Rodgers and the Green Bay Packers will face Tua Tagovailoa and the Miami Dolphins on Sunday. Rodgers led the Packers to a 24-12 victory over the Rams at a freezing Lambeau Field last Monday, improving the team's record to 6-8. It's been a disappointing season in many ways, but the Packers still technically have a path to the NFL playoff picture. They'll need to win out and get help from other teams along the way. The Dolphins have lost three in a row and will be hungry to get back in the win column, making them motivated to take care of business at home. The Dolphins are four-point favorites in the Week 16 NFL odds at Caesars Sportsbook. Which Week 16 NFL lines should you target with your Week 16 NFL bets? Before you make any Week 16 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season.  

The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.  

Now, the model has locked in five confident NFL best bets for Week 16. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 16 NFL picks at SportsLine.

No ad available

Top Week 16 NFL picks

After simulating every game 10,000 times, the model is high on the Minnesota Vikings (-3.5) to cover against the New York Giants. The Giants have won just once in their last five games.

Sunday's 20-12 win over Washington could have easily gone the other way. New York's previous win before then was a victory over the abysmal Texans on Nov. 13. New York has struggled mightily since then, making it ripe for the taking for Minnesota. The Vikings should be able to pile up points and hold the depleted New York offense in check. That is one reason the Vikings are covering the spread in over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 16 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a pair of underdogs that have a chance to win outright. You can only see the model's NFL Week 16 best bets and parlay at SportsLine

No ad available

What are the model's top Week 16 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 16 NFL best bets from a model on a 157-113 run on its top-rated picks, and find out.