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Losing to Southampton has been a rare occurrence for Chelsea since dropping back-to-back matches in 1993, as they have recorded 27 wins and 11 draws over their last 45 meetings across all competitions. The Blues have flourished on the road during that stretch, going 14-4-3 since those consecutive setbacks. Chelsea (2-1-1) hope to continue the trends when they visit Southampton (1-1-2) for an English Premier League matchup on Tuesday. The Blues were dominant in their last trip to Southampton, rolling to a 6-0 victory on Apr. 9.

Kickoff at St. Mary's Stadium in Southampton is set for 2:45 p.m. ET. The Blues are -155 favorites (risk $155 to win $100) on the 90-minute money line in the latest Chelsea vs. Southampton odds at Caesars Sportsbook, while the Saints are +420 underdogs. A regulation draw is priced at +300 and the over/under for total goals scored is 2.5. Before locking in any Southampton vs. Chelsea picks, make sure you check out the English Premier League predictions from SportsLine soccer insider Martin Green

After working in the sports betting industry for several years, Green became a professional sports writer and handicapper and has covered the game worldwide. Since then, his European soccer picks have been stunningly accurate. Green has generated almost $35,000 for $100 bettors since the 2017-18 season, and he has his finger on the pulse of the game all over the globe.

Now, Green has broken down Chelsea vs. Southampton from every angle and just locked in his picks and Premier League predictions. You can head to SportsLine now to see Green's picks. Here are the betting lines and trends for Southampton vs. Chelsea:

  • Chelsea vs. Southampton money line: Chelsea -155, Southampton +420, Draw +300
  • Chelsea vs. Southampton over/under: 2.5 goals
  • Chelsea vs. Southampton spread: Chelsea -0.5 (-170)
  • CHE: The Blues haven't lost at Southampton since March 30, 2013 (seven wins, two draws)
  • SOU: The Saints are 0-1-1 at home this season
  • Chelsea vs. Southampton picks: See picks here.

Why you should back Chelsea

Mason Mount is looking to come up with a performance similar to the one he had in the meeting with Southampton four months ago. The 23-year-old midfielder, who led the Blues with 11 goals last season, netted two of them in that match and also added an assist. Kai Havertz, also 23, converted in the 6-0 rout and scored in Chelsea's 1-1 draw against the Saints in the fourth round of the 2021-22 Carabao Cup - a match the Blues won on penalty kicks.

Raheem Sterling provided all the offense in Chelsea's 2-1 triumph over Leicester City on Saturday, scoring in the 47th minute to snap a scoreless deadlock and doubling the lead in the 63rd. They were the first two goals of the season for the 27-year-old winger, who inked a five-year deal in July after spending the previous seven campaigns with Manchester City. Sterling netted 13 goals in 2021-22, marking the fifth consecutive season he reached double figures.

Why you should back Southampton

The Saints recorded seven goals in three matches across all competitions before being shut out by Manchester United. Che Adams produced four of those goals, netting both in a 2-1 victory against Leicester City on Aug. 20 and scoring twice in Southampton's 3-0 triumph over Cambridge United in the second round of the 2022-23 Carabao Cup three days later. The 26-year-old forward recorded seven goals and three assists in 30 Premier League matches last season.

Midfielder Joe Aribo and defender Kyle Walker-Peters scored in the Saints' 2-2 draw against Leeds United on Aug. 13, while midfielder James Ward-Prowse netted the team's lone goal in its season-opening 4-1 loss to Tottenham. The 27-year-old Ward-Prowse accounted for Southampton's only score in a 3-1 setback at Chelsea on Oct. 2. Adams did the same in a 1-1 draw versus the Blues later that month in the fourth round of the 2021-22 Carabao Cup, a match Chelsea ultimately won on penalty kicks.

How to make Southampton vs. Chelsea picks

Green has scrutinized the Chelsea vs. Southampton match from every angle, and he is leaning Under on the goal total. He also provides his two confident best bets and a full breakdown of the match. He's only sharing his EPL picks here.

So, who wins Chelsea vs. Southampton on Tuesday? And where does all the betting value lie? Visit SportsLine now to see the best bets for Southampton vs. Chelsea, all from the European soccer expert who has generated almost $35,000 for $100 bettors over the past four seasons, and find out.