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A Big 12 battle is on tap between the Oklahoma State Cowboys and Iowa State Cyclones at 7 p.m. ET Wednesday at James H. Hilton Coliseum. Iowa State is 20-9 overall and 14-4 at home, while Oklahoma State is 13-15 overall and 2-8 on the road. Avery Anderson III scored a game-high 34 points for Oklahoma State in the last meeting between the two programs on January 26, but it wasn't enough to lead the Cowboys to the win, as the Cyclones took the 84-81 victory.

The Cyclones are favored by four points in the latest Iowa State vs. Oklahoma State odds from Caesars Sportsbook, and the over-under is set at 130.5. Before entering any Oklahoma State vs. Iowa State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,700 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Oklahoma State. You can head to SportsLine to see its picks. Here are several college basketball odds for Oklahoma State vs. Iowa State:

  • Iowa State vs. Oklahoma State spread: Iowa State -4
  • Iowa State vs. Oklahoma State over-under: 130.5 points

What you need to know about Iowa State

The Cyclones escaped with a win this past Saturday against Kansas State by the margin of a single free throw, 74-73. Iowa State's guard Tyrese Hunter was one of the most active players for the team and posted a double-double on 13 points and 10 assists in addition to seven rebounds. Izaiah Brockington is the top scorer for Iowa State this season, and he scored 17 points to go with eight rebounds in the win.

In Big 12 play this season, the Cyclones average the second-most assists per game and are led by Hunter, who averages 4.8 per contest, which is the third-highest mark in the conference. Iowa State has also allowed Big 12 opponents to come away with 8.3 offensive rebounds per contest, which is the highest mark in the conference. The Cyclones need to remember to box out Cowboys' forward Moussa Cisse, who has the seventh-most offensive boards in the Big 12 with 67 this year.

What you need to know about Oklahoma State

The Cowboys were close on Saturday but came out on the wrong side of a 66-62 final against the Oklahoma Sooners. Guard Bryce Thompson had one of his most ineffective games for Oklahoma State and finished with only nine points on 4-for-11 shooting in his 34 minutes. Anderson had another big performance in the loss, however, and scored 25 points to go with his six rebounds.

Iowa State ranks 15th in all of college basketball when it comes to takeaways, with 16.7 on average. That's tough news for Oklahoma State, the 16th-worst program in the country when it comes to turnovers per game, with 14.9 on average. Oklahoma State has struggled with its three-point shooting this season and has made just 30.1 of its attempts. That doesn't promise to get any better on Wednesday against an Iowa State side that holds others to hitting just 29.6 percent of their threes in 2021-22.

How to make Oklahoma State vs. Iowa State picks

The model has simulated Iowa State vs. Oklahoma State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

Who wins Iowa State vs. Oklahoma State? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks, and find out.