Entering the 2021 NCAA bracket, seven different seeds have cut down the nets since the field expanded to 64 teams in 1985. As you would expect, the No. 1 seed has won the most (22), followed by the No. 2 seed (5) and No. 3 seed (4). Four other seeds each claim one championship, but conspicuously missing among that group is the No. 5 seed. Every other top-8 seed in March Madness 2021 has won the NCAA Tournament at least once, so is No. 5 finally due to hoist the championship trophy?

The No. 5 seeds in the 2021 NCAA Tournament bracket are all at-large teams from major conferences. They include two Big East teams (Villanova and Creighton), one SEC team (Tennessee), and one Pac-12 team (Colorado). Of those four, Villanova has history on its side, as not only is it the only school to win the NCAA Tournament, but also the only No. 8 seed to win. Can the Wildcats make history with their third win in five tournaments? Before making any 2021 March Madness bracket predictions, be sure to check out the 2021 NCAA Tournament bracket picks from the proven computer model at SportsLine. 

Their proven projection model has simulated every game in the tournament 10,000 times. It absolutely crushed its March Madness picks last tournament, beating nearly 90 percent of all CBS Sports brackets one year after finishing in the top five percent. The model also nailed 14 teams in the Sweet 16 last time.

It knows how to spot an upset as well. The same model has produced brackets that have nailed 15 of the 26 first-round upsets by double-digit seeds the last four tournaments. It also nailed massive upsets last time, including huge wins by No. 13 seed UC-Irvine over No. 4 seed Kansas State, No. 10 seed Florida over No. 7 seed Nevada, and No. 12 seed Oregon over No. 5 seed Wisconsin.

There's simply no reason to rely on luck when there's proven technology to help you dominate your 2021 March Madness pools. Now, with the 2021 NCAA bracket being revealed, the model is simulating the matchups and its results are in. You can only see it over at SportsLine.

Three 2021 March Madness bracket games to watch

One 2021 March Madness matchup to keep an eye on: No. 8 North Carolina takes on No. 9 Wisconsin. The Tar Heels survived the always-tough ACC with an 18-10 record, falling to Florida State 69-66 in the ACC Tournament semifinals. North Carolina is the third-best rebounding team in the country, pulling down 43.2 boards per game, with Armando Bacot leading the way with 8.0 per contest. Wisconsin had similar luck in the Big 10, going 17-12 and falling to Iowa 62-57 in the conference tournament quarterfinals. D'Mitrik Trice delivers 13.7 points and 4.0 assists per game.

Also in the South Regional, sixth-seeded Texas Tech faces No. 11 Utah State. The Red Raiders rolled up a 17-10 record in the Big 12, bowing out to Texas in the Big 12 Tournament quarterfinals. Mac McClung goes for 15.7 points per game. Utah State went 20-8 in the Mountain West, but did not earn the league's automatic bid after falling to San Diego State in the Mountain West Tournament title game. Neemias Queta scores 15.1 points and grabs 10.0 rebounds per game.

The third matchup to watch is also in the South Regional, as No. 7 Florida goes up against No. 10 Virginia Tech. The Gators recorded a 14-9 record this season in the SEC, but lost to Tennessee in the SEC Tournament quarterfinals. Tre Mann delivers 16.0 points and 3.4 assists per game. Virginia Tech went 15-6, which included a setback against North Carolina in the ACC Tournament quarterfinals. Keve Aluma offers 15.6 points and 8.0 rebounds per game. You can see the model's picks for these games and every other here.

How to make 2021 NCAA bracket predictions

Who wins those three tournament-defining matchups? And which teams will make surprising runs through the 2021 NCAA Tournament bracket? With the model's track record of calling bracket-busting upsets, you'll want to see which stunners it is calling this year before locking in any NCAA bracket picks.

So what's the optimal NCAA Tournament 2021 bracket? And which underdogs will shock college basketball? Visit SportsLine now to see which double-digit seeds you can back with confidence, all from the model that's nailed 15 of the 26 double-digit seed upsets the past four years.