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The Indiana Hoosiers and No. 8 Purdue Boilermakers will meet in a Big Ten matchup at 2 p.m. ET on Saturday at Mackey Arena. The Boilermakers are 24-6 overall and 15-1 at home, while Indiana is 18-11 overall and 3-7 on the road. Purdue has dominated the rivalry, winning nine of the last 10 meetings and going 6-3-1 against the spread during that span.

However, Indiana has been the better team against the spread this season with a 15-13 record, while Purdue is 13-15. The Boilermakers are favored by 10 points in the latest Purdue vs. Indiana odds from Caesars Sportsbook and the over-under is 141. Before entering any Indiana vs. Purdue picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,700 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Purdue vs. Indiana. You can head to SportsLine to see its picks. Here are several college basketball odds for Purdue vs. Indiana:

  • Purdue vs. Indiana spread: Purdue -10
  • Purdue vs. Indiana over-under: 141 points

What you need to know about Purdue

Purdue lost 70-67 to the Wisconsin Badgers last Tuesday on a three-pointer from Wisconsin's guard Chucky Hepburn with 0:03 left to play. Despite the loss, Purdue had strong showings from center Zach Edey, who had 17 points in addition to nine rebounds, and guard Jaden Ivey, who had 22 points and five assists along with five boards.

The Boilermakers no longer have the regular-season Big Ten title in play, but they're still hoping to secure a top-two seed in the 2022 NCAA Tournament bracket and a rivalry matchup with Indiana always provides plenty of motivation. Purdue ranks third in the nation in field-goal percentage, but shot just 42.9 percent from the floor in the loss to Wisconsin.

What you need to know about Indiana

Speaking of close games: IU also fell on a last-second shot, losing 66-63 to the Rutgers Scarlet Knights last Wednesday at the hands of guard Ron Harper Jr. Indiana's defeat came about despite a quality game from forward Trayce Jackson-Davis, who had 19 points in addition to nine rebounds.

The Hoosiers won the first matchup against the Boilermakers on Jan. 20 to end a nine-game losing streak to their arch-rivals. Rob Phinisee scored 20 points off the bench in the victory and Xavier Johnson had 18 points. Jackson-Davis played only 11 minutes because of foul trouble. Having him play a more typical allotment of minutes could spell trouble for Purdue.

How to make Indiana vs. Purdue picks

The model has simulated Purdue vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in more than 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Purdue vs. Indiana? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.