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The Villanova Wildcats and the No. 2 Connecticut Huskies are set to square off in a Big East battle at 6:30 p.m. ET on Wednesday at the XL Center. The Huskies are 13-0 overall and 8-0 at home, while Villanova is 7-5 overall and 1-2 on the road. It's Dan Hurley's fifth season at the helm for the Huskies and UConn is coming off back-to-back NCAA Tournament appearances. Meanwhile, Villanova is in its first season under Kyle Neptune after Jay Wright led the program for 20 years.

The Huskies are favored by 12 points in the latest UConn vs. Villanova odds from Caesars Sportsbook, and the over/under is set at 136.5. Before entering any Villanova vs. UConn picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 7 of the 2022-23 college basketball season on a strong 19-12 roll on all top-rated CBB picks, returning more than $200. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Connecticut vs. Villanova. You can head to SportsLine to see its picks. Here are several college basketball odds for UConn vs. Villanova:

  • UConn vs. Villanova spread: UConn -12
  • UConn vs. Villanova over/under: 136.5 points
  • UConn vs. Villanova money line: UConn -800, Villanova +550
  • UConn vs. Villanova picks: See picks here

What you need to know about Connecticut

The stars were brightly shining for UConn in an 84-73 win over the Georgetown Hoyas last week. Connecticut's guard Tristen Newton was one of the most active players for the squad, picking up 17 points and seven assists. The Huskies shot 49.2% from the floor in the victory and they've been one of the most efficient offensive teams in the nation this season.

UConn is shooting 48.6% from the floor as a team and 37.3% from the 3-point line while averaging 83.6 points per game. At the same time, the Huskies have also been strong defensively as their 58.6 points allowed per game ranks 12th nationally. Connecticut has won all 13 of its games this season by double-digits.

What you need to know about Villanova

Meanwhile, the stars were brightly shining for Villanova in a 78-63 victory over the St. John's Red Storm last Wednesday. Villanova got double-digit scoring from four players: forward Eric Dixon (18), forward Brandon Slater (16), guard Caleb Daniels (13) and guard Jordan Longino (13).

It was Villanova's fifth win in a row after an abysmal 2-5 start to the season and it appears that the roster is starting to find its rhythm under Neptune. The Wildcats have held their last three opponents to under 40.0% shooting from the floor and their last four opponents have shot 31.0% or worse from the 3-point line.

How to make UConn vs. Villanova picks

The model has simulated Connecticut vs. Villanova 10,000 times and the results are in. We can tell you that the model is leaning Over and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins UConn vs. Villanova? And which side of the spread is hitting well over 50% of the time? Visit SportsLine to see which side of the Villanova vs. Connecticut spread to jump on, all from the advanced model that is up over $1,400 on its college basketball picks the last six years, and find out.