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The second-ranked Alabama Crimson Tide will look for a repeat performance from last year's dominant showing against the LSU Tigers when they meet in a key SEC West matchup on Saturday night. The Crimson Tide (7-1, 4-1) throttled LSU 55-17 in their meeting at Baton Rouge, La., in 2020. It was Alabama's ninth win in the past 10 games against the Tigers (4-4, 2-3). LSU, however, won the last game in the series played at Tuscaloosa, Ala., a wild 46-41 triumph in 2019.

Kickoff from Bryant-Denny Stadium is set for 7 p.m. ET. Alabama can score points and is averaging 45.9 points per game this season, second-best in the nation, while LSU averages 30.5, 50th-best. The Crimson Tide are favored by 28.5 points in the latest LSU vs. Alabama odds from Caesars Sportsbook, while the over-under for total points scored is 67. Before making any Alabama vs. LSU picks, make sure you check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Alabama vs. LSU and just revealed its coveted CFB picks and predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for LSU vs. Alabama:

  • LSU vs. Alabama spread: Alabama -28.5
  • LSU vs. Alabama over-under: 67 points
  • LSU vs. Alabama money line: LSU +2000, Alabama -10000
  • LSU: The Tigers are 11-3 against the spread in their last 14 games following an ATS loss
  • ALA: The Crimson Tide are 11-2 ATS in their last 13 games as a home favorite
Featured Game | Alabama Crimson Tide vs. LSU Tigers

Why Alabama can cover

Sophomore Bryce Young has been sharp on third down in his first season as the Crimson Tide's starting quarterback. He is completing 74.6 percent of his third-down passing attempts (53 of 71) for 860 yards and eight touchdowns. He has converted first downs on 42 of those 71 third-down tries (59.2 percent). 

Defensively, Alabama has forced at least one turnover in 86 of the last 93 games, dating back to the start of the 2015 season. During that stretch, the Crimson Tide have forced 155 turnovers, including 102 interceptions, and returned 35 of those for touchdowns. Alabama is tied for 24th nationally and second in the SEC in turnovers gained with 13 this season. The Crimson Tide are also tied for 15th nationally in turnover margin at plus-.88 per game.

Why LSU can cover

The Tigers have had some success against the Crimson Tide, winning 10 of 22 meetings since 2000. To pull off a stunner, LSU will look for another big game from junior running back Tyrion Davis-Price, who leads the team in rushing. He has carried 120 times for 627 yards (5.2 average) and six touchdowns. Davis-Price has rushed for 100 or more yards in two games, including an incredible 287 yards on 36 carries (8.0 average) with three touchdowns in the Tigers' 49-42 win over then-No. 20 Florida on Oct. 16. He also carried 22 times for 147 yards and two touchdowns at Kentucky on Oct. 9.

Defensively, LSU is led by senior linebacker Damone Clark, who has a team-high 99 tackles, including 57 solo, with one sack for nine yards. Clark also has forced two fumbles, recovered one, broke up one pass and intercepted another. In his last game against Ole Miss, he registered 19 tackles, including seven solo, with a sack. He has double-digit tackle totals in five consecutive games.

How to make LSU vs. Alabama picks

SportsLine's model is leaning over on the total, projecting 72 combined points. The model also says one side of the spread hits in over 50 percent of simulations. You can only get the model's pick at SportsLine

So who wins Alabama vs. LSU? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.