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The Louisville Cardinals will try to end their drought in South Florida when they hit the road to face the Miami (FL) Hurricanes in an ACC showdown on Saturday at Hard Rock Stadium outside of Miami. In seven all-time matchups against the Hurricanes in Miami, the Cardinals are 0-6-1. Louisville has been dominated by the Hurricanes in the head-to-head series overall, 3-11-1, and has lost the last two matchups. The Cardinals (9-1 overall, 6-1 in ACC) enter Saturday's game with a chance to clinch a spot in the ACC Championship Game with a victory over Miami (6-4, 2-4). 

Kickoff is scheduled for noon ET. The Hurricanes are 1-point favorites in the latest Louisville vs. Miami odds. The over/under for total points scored is 46.5. Before you make any Miami vs. Louisville picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a strong profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now, the model has set its sights on Louisville vs. Miami and just locked in its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for Miami vs. Louisville:

  • Louisville vs. Miami spread: Miami -1
  • Louisville vs. Miami over/under: 46.5 points
  • Louisville vs. Miami money line: Miami -115, Louisville -105
  • LOU: The Cardinals are No. 3 in the country in red zone defense (.667)
  • MIA: The Hurricanes rank sixth in the nation in rushing defense (86.0 yards allowed per game)
  • Louisville vs. Miami: See picks at SportsLine  
  • Louisville vs. Miami: live stream: fubo (try for free)

Why Louisville can cover

Cardinals running back Isaac Guerendo enters the game on a bit of a roll. The 6-foot-1, 225-pound transfer from Wisconsin has rushed for 240 yards and four scores in the last two games on just 17 carries (14.1 yards per carry). In the team's last game, against Virginia, he scored the game-winning touchdown on a career-long 73-yard run.

In addition, Louisville faces a Miami team that has been losing the turnover battle all season. With 20 turnovers committed and just 15 forced, the Hurricanes rank 11th in the conference and 104th in the country in turnover margin per game (-0.50). Just eight teams in the country have committed more turnovers than Miami. See which team to pick here.

Why Miami can cover

The Hurricanes defense has been excellent this season at generating pressure on quarterbacks. Miami is tied for seventh in the country in sacks per game (3.30) and is averaging 4.2 sacks per game over its last five contests. Junior linebacker Francisco Mauigoa and freshman lineman Rueben Bain Jr. share the team lead in sacks (6.5).

In addition, the Hurricanes have an edge in special teams play. Miami ranks 11th in the country in kickoff returns (25.3 yards per return). Meanwhile the Cardinals are 118th in the nation in kickoff returns (16.4) as well as 109th in punt returns (4.7). See which team to pick here.

How to make Louisville vs. Miami picks

SportsLine's model is leaning Over the point total, predicting a combined 56 points. The model also says one side of the spread hits well over 60% of the time. You can see the model's CFB picks at SportsLine

So who wins Miami vs. Louisville, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of well over $2,000 on its top-rated college football spread picks, and find out.