The two top independent programs in the nation will go head-to-head on Saturday when the No. 16 BYU Cougars and the Notre Dame Fighting Irish face off at 7:30 p.m. ET at Allegiant Stadium in Houston. BYU is 4-1 while Notre Dame is 2-2. Notre Dame has a 4-2 lead in the all-time series, but this will be the first time the two programs have met since 2005 and it's going to be a critical contest for both programs if they're hoping to play in a New Year's Six bowl. Notre Dame is 2-2 against the spread this season while BYU is 2-3 against the number after failing to cover in their last thre games. 

The Fighting Irish are favored by 3.5 points in the latest Notre Dame vs. BYU odds from Caesars Sportsbook and the over/under is set at 51.5. Before making any BYU vs. Notre Dame picks, you'll want to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. BYU and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting line for Notre Dame vs. BYU:

  • Notre Dame vs. BYU spread: Notre Dame -3.5
  • Notre Dame vs. BYU over/under: 51.5 points
  • Notre Dame vs. BYU picks: See picks here
Featured Game | Notre Dame Fighting Irish vs. BYU Cougars

What you need to know about Notre Dame

Last week, the Fighting Irish turned the game against the North Carolina Tar Heels into a track meet and took the gold after outgaining them 576 yards to 367. Notre Dame walked away with a 45-32 win. Their success was spearheaded by the efforts of running back Audric Estime, who rushed for two touchdowns and 134 yards on 17 carries, and quarterback Drew Pyne, who passed for three touchdowns and 289 yards on 34 attempts.

The offensive outburst was a welcomed sight for first-year head coach Marcus Freeman after the Irish had generated just 901 yards and 55 points in their first three games against Ohio State, Marshall and California. The Notre Dame defense also generated its first turnover of the year in the win over North Carolina but still has a turnover differential of -4 on the season. They have, however, been able to generate a lot of pressure early in the season with 13 sacks through four games.

What you need to know about BYU

Meanwhile, it was all tied up 17-17 at the half for BYU and the Utah State Aggies on Thursday, but BYU stepped up in the second half for a 38-26 victory. BYU QB Jaren Hall passed for three touchdowns and 273 yards on 27 attempts. Hall's top receiver on the day was Kody Epps, who caught five passes for 86 yards and a score.

The BYU defense forced three turnovers in the win over Utah State and is now allowing just 4.9 yards per play and 338.2 yards per game for the season. Ben Bywater and Max Tooley have been two key playmakers for that unit, with Bywater recording 37 tackles, 2.5 tackles for loss, a sack and two interceptions while Tooley has 29 tackles, 2 tackles for loss, a sack and two interceptions.

How to make BYU vs. Notre Dame picks

The model has simulated Notre Dame vs. BYU 10,000 times and the results are in. We can tell you that the model is leaning over on the point total. It's also generated a point-spread pick where one side has all the value. You can only see the pick at SportsLine.

Who will win Notre Dame vs. BYU? And which side of the spread has all the value? Visit SportsLine now to see which side of the spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.