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The Notre Dame Fighting Irish will take on the Virginia Cavaliers at 7:30 p.m. ET on Saturday in Scott Stadium. Virginia is 6-3 overall and 4-1 at home, while the Fighting Irish are 8-1 overall and 2-0 on the road. The two programs have gone head-to-head three times in their history with Notre Dame winning all three matchups, including a 35-20 win in the most recent matchup in 2019.

However, both teams are 6-3 against the spread this season and Virginia has covered in eight of its last nine games at home. The Fighting Irish are favored by 5.5-points in the latest Notre Dame vs. Virginia odds from Caesars Sportsbook, while the over-under is set at 64. Before entering any Virginia vs. Notre Dame picks, you'll want to see the college football predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 11 of the 2021 season on a 31-20 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Virginia vs. Notre Dame. You can head to SportsLine to see its picks. Here are several college football odds for Notre Dame vs. Virginia:

  • Virginia vs. Notre Dame spread: Virginia +5.5
  • Notre Dame vs. Virginia over-under: 64 points

What you need to know about Virginia

The contest between Virginia and the BYU Cougars two weeks ago was a high-scoring battle, with the Cavaliers falling 66-49. Virginia might have lost, but QB Brennan Armstrong had a massive game. He passed for four touchdowns and 327 yards on 34 attempts in addition to rushing for two touchdowns and 94 yards.

Armstrong has had an absolutely massive year running Bronco Mendenhall's offense. The second-year starter has thrown for 3,557 yards and 27 touchdowns and has also rushed for 271 yards and seven scores. He ranks first in the ACC in passing yards this season and is No. 2 in the nation. 

What you need to know about Notre Dame

Meanwhile, when you finish with 246 more yards than your opponent like Notre Dame did on Saturday, a favorable outcome is almost sure to follow. The Fighting Irish made easy work of the Navy Midshipmen and carried off a 34-6 win. Notre Dame's success was spearheaded by the efforts of running back Kyren Williams, who punched in one rushing touchdown, and wide receiver Kevin Austin Jr., who caught six passes for one touchdown and 139 yards.

Williams has been Notre Dame's best and most versatile offensive weapon the past two seasons. He's rushed for 795 yards and nine touchdowns this year, while adding 34 receptions for 293 yards and three more touchdowns through the air. Since the start of 2020, Williams has now produced 2,526 scrimmage yards and 26 scores and he could run roughshod over a Virginia defense allowing 219.1 rushing yards per game this year.

How to make Notre Dame vs. Virginia picks

The model has simulated Virginia vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Notre Dame vs. Virginia? And which side of the spread hits over 60 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college football picks.