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The Michigan Wolverines are 58-51-6 in their all-time series against the Big Ten Conference-rival Ohio State Buckeyes but have lost eight consecutive meetings and 15 of the last 16. Michigan is 31-24-4 versus Ohio State in Ann Arbor but has dropped four straight matchups and seven of the last eight at home. The Wolverines (10-1, 7-1) hope to end both slides when they host the Buckeyes (10-1, 8-0) for the 117th edition of "The Game" on Saturday. Michigan's last victory against Ohio State came in 2011, when it recorded a 40-34 victory on its own field.

Kickoff at Michigan Stadium in Ann Arbor is set for noon ET. The Buckeyes are seven-point favorites in the latest Ohio State vs. Michigan odds from Caesars Sportsbook, while the over-under for total points scored is 64.5. Before locking in any Michigan vs. Ohio State picks or college football predictions, you need to see what the red-hot SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ohio State vs. Michigan and just locked in its picks and predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Michigan vs. Ohio State: 

  • Ohio State vs. Michigan spread: Buckeyes -7
  • Ohio State vs. Michigan over-under: 64.5 points 
  • Ohio State vs. Michigan money line: Buckeyes -300, Wolverines +240
  • OSU: The Buckeyes are 6-2 against the spread in their last eight visits to Ann Arbor 
  • MICH: The Wolverines are 1-6 ATS in their last seven games against teams with winning records
Featured Game | Michigan Wolverines vs. Ohio State Buckeyes

Why Ohio State can cover

The Buckeyes just don't lose conference games anymore, as they have won 23 consecutive contests against Big Ten rivals since suffering a 49-20 loss at Purdue on Oct. 20, 2018. In addition, they own a 21-game winning streak versus ranked conference opponents. Ohio State also has won all 13 of its true road games since the setback at Purdue and 12 straight meetings with ranked opponents away from home.

Redshirt freshman quarterback C.J. Stroud is coming off his fourth 400-yard performance of the season and ranks eighth in the nation in both passing yards (3,468) and completion percentage (71.1) while tying for fourth in touchdown tosses (36). Chris Olave is tied for second in the country as he has hauled in 13 of those scoring passes, including 11 during his current eight-game streak, and is coming off his fifth 100-yard effort of the year as he gained 140 on seven catches against the Spartans. Freshman TreVeyon Henderson has run for a TD in eight of his 11 games and is tied for 10th in the nation with 14 rushing touchdowns while ranking 19th with 1,098 yards on the ground.

Why Michigan can cover

Ohio State is tied for 12th in the nation with 35 sacks, but the Wolverines possess one of the country's top offensive lines. Michigan gives up the fifth-fewest sacks per game at 0.82 and ranks first in fewest tackles for loss allowed with an average of 2.18. The unit has helped senior running back Hassan Haskins post his first 1,000-yard season (1,063), which includes five 100-yard performances, and record five two-touchdown efforts en route to 13 rushing TDs.

Three of the nine sacks allowed by the Wolverines came against Indiana on Nov. 6, the only game this season in which Cade McNamara was taken down more than once. The junior signal-caller has connected with nine different receivers for 14 touchdowns, registering at least two in each of his last four contests. McNamara threw one of his two scoring passes in last week's 59-18 rout at Maryland to rookie running back Donovan Edwards, who finished with more receiving yards on 10 catches in that game (170) than he has amassed on 27 rushing attempts in eight contests this year (149).

How to make Ohio State vs. Michigan picks

SportsLine's model is leaning over on the total, projecting the teams to combine for 65 points. It also has generated an against-the-spread pick that cashes in 60 percent of simulations. You can only get the model's Michigan vs. Ohio State pick at SportsLine.

So who wins Michigan vs. Ohio State? And which side of the spread hits 60 percent of the time? Visit SportsLine now to see which side of the Ohio State vs. Michigan spread to back, all from the advanced model that is up almost $3,700 on its top-rated college football spread picks, and find out.