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The No. 11 Tennessee Volunteers take the field at Neyland Stadium for the program's SEC opener on Saturday. Tennessee hosts the No. 20 Florida Gators with the chance to build on an unbeaten record. The Vols are 3-0 after a blowout win over Akron, and Tennessee is seeking its first win over Florida since 2016. Florida is 2-1 overall, though the Gators lost their first SEC game against Kentucky.

Kickoff in this SEC on CBS matchup is set for 3:30 p.m. ET in Knoxville, Tenn. Caesars Sportsbook lists Tennessee as a 10.5-point favorite. The total number of points Vegas thinks will be scored, or the over/under, is 62.5 in the latest Florida vs. Tennessee odds. Saturday's game can be seen live on CBS and streamed live on Paramount+ with their must-have Premium plan. 

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And before making any Tennessee vs. Florida picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Florida vs. Tennessee and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Tennessee vs. Florida:

  • Florida vs. Tennessee spread: Tennessee -10.5
  • Florida vs. Tennessee over/under: 62.5 points
  • Florida vs. Tennessee money line: Tennessee -350, Florida +275
  • FLA: The Gators are 1-2 against the spread this season
  • TENN: The Volunteers are 3-0 against the spread in 2022
  • Florida vs. Tennessee picks: See picks at SportsLine
  • Florida vs. Tennessee streaming: Watch on Paramount+
Featured Game | Tennessee Volunteers vs. Florida Gators

Why Florida can cover

The Gators have been stingy against the pass this season. Florida is giving up only 178 passing yards per game with opponents completing only 56% of passes against the Gators. Florida has allowed only two touchdown passes with four interceptions, and that resistance is key against the high-powered Tennessee offense. The Gators are also producing effectively on the ground on offense, averaging 212 rushing yards per game. Florida has a balanced rushing attack with four players generating at least 100 rushing yards in only three games, and the Gators are averaging 6.4 yards per carry. Florida also holds the edge in recent history against Tennessee. 

The Gators have won 16 of the last 17 meetings against the Vols, including the last four meetings. In those last four games, Florida has scored at least 31 points each time, and Florida is outscoring Tennessee by more than 23 points per game while outgaining the Volunteers by more than 100 yards per contest. Finally, the Gators could benefit from the absence of star Tennessee receiver Cedric Tillman. He left last week's game with a lower-body injury, and Tennessee hasn't provided an official update on his status for Saturday. 

Why Tennessee can cover 

Though Florida has the recent success in the head-to-head series, Tennessee can benefit from the struggles of its opponent. The Gators have not won back-to-back games since the first two games of 2021, and Florida is on a four-game road losing streak. Florida is also just 2-8 against ranked opponents dating back to 2019, and the Gators are struggling through the air on offense. Florida has the fewest passing yards and the worst completion rate of any SEC team this season, and Anthony Richardson has multiple interceptions in back-to-back games. 

Richardson is also one of only four players in FBS with no touchdown passes and at least four interceptions. In addition, Florida has only 10 plays of at least 20 yards this season, which ties for the fewest among SEC teams with South Carolina. Tennessee's offense currently sits atop the SEC in total offense, scoring offense and yards per pass attempt, with top-two marks in passing offense and rushing touchdowns. The Vols also have the benefit of a raucous crowd at Neyland Stadium, and Tennessee is giving up only 14.3 points per game in 2022.

How to make Florida vs. Tennessee picks

SportsLine's model is leaning Under on the total, projecting 59 combined points. It also says one side of the spread hits well over 50% of the time. You can only get the pick at SportsLine.

So who wins Tennessee vs. Florida? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that is up more than $3,300 on its top-rated college football spread picks, and find out.