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Virginia Tech will try to build on its season-opening victory when it hosts Purdue in a non-conference battle on Saturday afternoon. The Hokies cruised to a 36-17 win over Old Dominion last week, scoring the game's final 13 points to cover the 16.5-point spread. Purdue is coming off a heartbreaking loss, falling to Fresno State in a 39-35 final. The Boilermakers held an 11-point third-quarter lead, but they were unable to hold on down the stretch.

Kickoff is set for noon ET at Lane Stadium/Worsham Field in Blacksburg. The latest Virginia Tech vs. Purdue odds via the SportsLine consensus list the Hokies as 2-point favorites, with the over/under at 49. Virginia Tech beat Purdue in a 51-24 final when these teams met in 2015. Before making any Purdue vs. Virginia Tech picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model

The SportsLine Projection Model simulates every FBS college football game 10,000 times. The proprietary computer model is off to a fast 4-2 start on all-top rated college football picks this season. Since its inception, it has generated a stunning profit of more than $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns. 

Now, the model has set its sights on Purdue vs. Virginia Tech and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Virginia Tech vs. Purdue:

  • Virginia Tech vs. Purdue spread: Virginia Tech -2
  • Virginia Tech vs. Purdue over/under: 49 points
  • Virginia Tech vs. Purdue money line: Virginia Tech -125, Purdue +104
  • Virginia Tech vs. Purdue picks: See picks at SportsLine

Why Virginia Tech can cover 

The money has been pouring in on Virginia Tech, moving the Hokies from 1-point underdogs to 2-point favorites. New starting quarterback Grant Wells threw three touchdown passes and rushed for another score in the win over Old Dominion last week after winning the starting job over Baylor transfer Kyron Drones. The Hokies had scored 30 points or less in 14 consecutive games, and they had lost to the Monarchs in last year's season opener.

Senior wide receiver Ali Jennings caught five passes for 72 yards and two touchdowns, as Virginia Tech covered the spread for the fourth time in its last six games dating back to last season. Purdue is coming off a brutal loss to Fresno State, blowing a double-digit lead as it failed to cover for the fourth time in its last five games. The Boilermakers have lost four of their last five games against ACC opponents, while Virginia Tech is undefeated in its last five Week 2 contests. 

Why Purdue can cover

Purdue was ultimately unable to get past Fresno State in a shootout, but new quarterback Hudson Card put together a quality debut. The former Texas starter racked up 254 passing yards, two touchdowns and no interceptions, leading the offense to 35 points. Sophomore wide receiver Deion Burks finished with 152 receiving yards and two touchdowns on just four receptions. 

Card gives the Boilermakers a dual-threat quarterback of its own, rushing for 29 yards against Fresno State. Virginia Tech struggled to get its rushing attack going against Old Dominion, with junior Bhayshul Tuten averaging less than three yards per carry on 19 attempts. The Boilermakers have covered the spread in four of their last five road games, and Virginia Tech only has two wins in its last nine outings. See which team to pick here.

How to make Purdue vs. Virginia Tech picks

SportsLine's model is leaning Under on the point total. It has also generated an against-the-spread pick that hits in well over 60% of simulations. You can only get the model's picks at SportsLine

So who wins Virginia Tech vs. Purdue, and which side of the spread hits in well over 60% of simulations? Visit SportsLine now to see which side of the Purdue vs. Virginia Tech spread to jump on, all from the advanced computer model that's up more than $2,500 on its top-rated college football spread picks since its inception, and find out.