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The St. Louis Cardinals and San Francisco Giants square off in a rubber match on Sunday evening. The Cardinals and Giants wrap up a three-game series on Sunday Night Baseball, with both teams winning a game in the previous 48 hours. St. Louis won 4-0 on Saturday after an 8-2 win for the Giants on Friday. The Cardinals are 18-15 overall, while the Giants are 20-13 so far in 2022. 

First pitch is at 7:08 p.m. ET in St. Louis. Caesars Sportsbook lists San Francisco as a -135 favorite (risk $135 to win $100) on the money line, while the over-under, or total number of runs Vegas thinks will be scored, is seven in the latest Giants vs. Cardinals odds. Before you make any Cardinals vs. Giants picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 31-19 roll on top-rated MLB money-line picks through five weeks, returning almost $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Giants vs. Cardinals and just locked in its picks and MLB predictions. You can head to SportsLine now to see the picks. Here are several MLB betting lines and trends for Cardinals vs. Giants: 

  • Giants vs. Cardinals money line: Giants -135, Cardinals +115
  • Giants vs. Cardinals over-under: 7 runs
  • Giants vs. Cardinals run line: Giants -1.5 (+125)
  • SF: The Giants are 9-6 in road games
  • STL: The Cardinals are 9-8 in home games
Featured Game | St. Louis Cardinals vs. San Francisco Giants

Why you should back the Giants

San Francisco is deploying one of the best starting pitchers in the National League in Carlos Rodon. The left-hander was a 2021 All-Star with a top-five finish in Cy Young voting last season, and Rodon was dominant to the tune of a 2.37 ERA with nearly 13 strikeouts per inning. In 2022, he picked up where he left off, posting a 1.80 ERA in his first six starts. In those six outings, Rodon has 53 strikeouts in 35 innings, and he has yet to allow a home run this season. 

Opponents have a dismal .459 OPS against Rodon in 2022, and he has been dominant on the road with a 1.50 ERA away from San Francisco. Once Rodon leaves the game, the Giants can also take advantage of a very strong bullpen. San Francisco ranks in the top three of the National League in wins above replacement from relievers, and Giants relievers have a 3.46 ERA to go along with only 2.81 walks per nine innings.

Why you should back the Cardinals

The Cardinals have standout characteristics on offense, including National League-leading marks in stolen bases (28) and strikeout rate (19.7 percent). St. Louis also projects quite well in run prevention, however, and much of that comes from veteran right-hander Adam Wainwright. The three-time All-Star threw seven shutout innings with only one hit allowed in his last start, and Wainwright has a 3.18 ERA across six outings in 2022. That comes after a 3.05 ERA in 206.1 innings last season, and Wainwright has a career walk rate of 2.4 per nine innings. 

Right-handed batters struggle mightily against Wainwright, posting only a .560 OPS this season, and Wainwright has a 2.25 ERA at Busch Stadium in 2022. The Cardinals also have a stout bullpen, with St. Louis currently leading the National League in ERA (3.17) and ground ball rate (47.7 percent) from relievers.

How to make Giants vs. Cardinals picks

SportsLine's model is leaning over on the run total, and it says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Giants vs. Cardinals? And which side has all the value? Visit SportsLine now to see which side of Giants vs. Cardinals you need to jump on Sunday, all from the model that has crushed its MLB picks, and find out.