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Guaranteed Rate Field hosts a matinee baseball contest on Monday afternoon. The Chicago White Sox host the Los Angeles Angels in the finale of a four-game set. Chicago looks to even the series with a victory, though the White Sox are off to a slow start overall. Los Angeles is red-hot at 15-8 overall and 7-1 in the last eight games. Anthony Rendon (rest) and Shohei Ohtani (groin) are not in the lineup for Los Angeles. 

Caesars Sportsbook lists Chicago as the -145 money-line favorite (risk $145 to win $100) for  this 2:10 p.m. ET first pitch. The total number of runs Vegas thinks will be scored, or the over-under, is 7.5 in the latest Angels vs. White Sox odds. Before making any White Sox vs. Angels picks, you need to check out the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 28-13 roll on top-rated MLB picks through four weeks, returning over $1,100 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on White Sox vs. Angels, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Angels vs. White Sox:

  • Angels vs. White Sox money line: White Sox -145, Angels +125
  • Angels vs. White Sox over-under: 7.5 runs
  • Angels vs. White Sox run line: White Sox -1.5 (+145)
  • LAA: The Angels are 7-3 on the road
  • CHI: The White Sox are 6-6 at home
Featured Game | Chicago White Sox vs. Los Angeles Angels

Why you should back the Angels

The Angels are off to an unbelievable start on offense in 2022, leading the American League in batting average, on-base percentage, and slugging percentage at this point. In contrast, the White Sox rank well below the AL average in key offensive categories including runs scored, doubles, walks, on-base percentage and batting average. The Angels also have a red-hot starting pitcher taking the ball on Monday in 25-year-old left-hander Patrick Sandoval

The southpaw has thrown 15 scoreless innings this season, allowing only one baserunner per inning with 20 strikeouts and six walks. Since the beginning of the 2021 season, Sandoval has a 3.09 ERA across more than 100 innings, and he has found a new gear to begin this campaign. Left-handers particularly scuffle against Sandoval historically, as he uses the platoon advantage to limit the opposition to a .684 OPS in his career against left-handers.

Why you should back the White Sox

Chicago's offense is off to a slow start, but there is talent on the roster. The White Sox, with a similar squad, finished in the top four of the American League in myriad categories in 2021, including hits, walks, batting average, and on-base percentage. In 2022, the White Sox have the second-fewest strikeouts in the American League, and brighter days are ahead from a run production standpoint. 

On the mound, Dylan Cease takes the ball as the team's starter on Monday, and the 26-year-old right-hander owns a 3.27 ERA in 22 innings and four starts this season. Cease has 28 strikeouts in those 22 innings, and he led the American League in strikeout rate last season at 12.3 strikeouts per nine innings. Right-handers have trouble against Cease with a .688 OPS against him in his career, and Cease has a very solid 3.84 ERA to his name since the beginning of the 2021 season.

How to make White Sox vs. Angels picks

SportsLine's model is leaning over on the run total, projecting 9.1 combined runs, and it says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Angels vs. White Sox? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.