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Justin Herbert and Dak Prescott have been two of the most prolific quarterbacks of the last several years, but both players are still stuck in a tier of current NFL quarterbacks who haven't had significant postseason successes. They'll go head-to-head on Monday Night Football in Week 6 with the Los Angeles Chargers hosting the Dallas Cowboys and both will be popular options for NFL DFS lineups. How much exposure should you have to each in your NFL DFS picks?

These two offenses rank top 10 in the NFL in scoring, so there's potential for a high-scoring affair, which could widen the NFL DFS player pool for MNF. However, an effective NFL DFS strategy is all about striking the right balance to maximize potential scoring output. Before locking in any NFL DFS picks for Cowboys vs. Chargers on Monday Night Football on sites like DraftKings and FanDuel, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings.

He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once.

Now, McClure has turned his attention to Cowboys vs. Chargers on Monday Night Football and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Cowboys vs. Chargers

One of McClure's top NFL DFS picks for Monday Night Football is Cowboys tight end Jake Ferguson. With Dalton Schultz leaving to join the Texans this offseason after catching 198 passes for 2,000 yards and 17 touchdowns over the last three seasons, Ferguson has moved to the top of the Cowboys' depth chart at tight end.

Ferguson has caught 20 passes for 175 yards and a touchdown over the first five games of the season, putting him on pace for nearly 70 receptions and 600 yards. He's been targeted at least seven times in three of those five contests and his 26.9% targets per route run rate is the second-highest among tight ends.

Part of McClure's optimal NFL DFS strategy also includes rostering Chargers wide receiver Keenan Allen. At 31-years-old and coming off a season in which he missed seven games with a soft tissue injury, there were questions about whether Allen would continue to produce as a No. 1 receiver or if he'd cede that role to Mike Williams and potentially first-round pick Quentin Johnston.

Instead, Allen is on pace for a career year, catching 35 passes for 434 yards and three touchdowns over the first four games. Allen also threw a 49-yard touchdown pass and you can only expect his involvement in the offense to increase with Williams out for the season after tearing his ACL. Dallas is without top cornerback Trevon Diggs (ACL) and Allen should be targeted frequently on MNF. See the rest of McClure's NFL DFS player pool right here.

How to set NFL DFS lineups for Chargers vs. Cowboys

McClure is also targeting an undervalued player who is set to explode for huge numbers on Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here

So who is Mike McClure putting in his optimal NFL DFS lineups for Monday Night Football? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.