The defending NFC champion Philadelphia Eagles will host the Minnesota Vikings on Thursday Night Football in the first game of the Week 2 NFL schedule. Both offenses are full of stars with big play capability, giving this game a deep showdown NFL DFS player pool. One player who could be among the most popular TNF NFL DFS picks is Vikings wide receiver Justin Jefferson, the highest priced player on DraftKings and FanDuel. Philadelphia also has a pair of wide receivers in A.J. Brown and DeVonta Smith, who could both be popular choices in NFL DFS lineups for Thursday. Should Jefferson, Brown, or Smith be part of your NFL DFS strategy? Should you build your NFL DFS stacks around Jalen Hurts or Kirk Cousins?

Kickoff is set for 8:15 p.m. ET. Before making any NFL DFS picks for Vikings vs. Eagles on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor

Kaylor is a NFL and DFS expert for SportsLine who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who cashed big all season in 2022, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor hit on epic NFL DFS picks all season in 2022. He was all over Travis Kelce's four-touchdown performance against the Raiders on Monday Night Football, Kirk Cousins' 460-yard, four-TD performance on Thanksgiving Day, and T.J. Hockenson's 13 catches for 109 yards and two touchdowns in Week 15.

Now, Kaylor has turned his attention to Vikings vs. Eagles on Thursday Night Football Week 2 and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Vikings vs. Eagles on TNF

One of Kaylor's favorite DFS picks for the Minnesota vs. Philadelphia TNF game is Vikings wide receiver Justin Jefferson. The 24-year-old is coming off one of the best single seasons by a wide receiver in NFL history, catching 128 passes for 1,809 yards and eight touchdowns. With Minnesota's addition of rookie wide receiver Jordan Addison, opposing defenses won't be able to focus solely on slowing down Jefferson, and Kaylor expects the former LSU standout to thrive all season.

"At this point, Justin Jefferson is basically becoming a must-start player in Showdown DFS formats. There's really no way around it. The 24-year-old wide receiver is the best player at his position in the NFL today and in head coach Kevin O'Connell's offense, he will likely have a floor of 10 targets per game going forward. In a matchup where the Vikings could be playing from behind for most of the game, I am anticipating a massive fantasy stat line for Jefferson against the Eagles," Kaylor told SportsLine.

Part of Kaylor's MNF DFS strategy also includes rostering Eagles quarterback Jalen Hurts. The 25-year-old was one of the top contenders to take home NFL MVP honors in 2022 before an injury slowed him down towards the end of the regular season. Since taking over as the Eagles' full-time starting quarterback, Hurts has compiled a 23-8 regular season record and led the team to last year's NFC Championship.

In 2022, Hurts completed 306 of 460 passes for 3,701 yards, 22 touchdowns, six interceptions, and a quarterback rating of 101.5. He also rushed for 760 yards and 13 TDs. The former Alabama and Oklahoma standout has been one of the most consistently productive fantasy quarterbacks in the NFL over the last two years and Kaylor expects that to continue on Thursday Night Football. You can see the rest of Kaylor's NFL DFS picks here.

How to build NFL DFS lineups for Eagles vs. Vikings on TNF

Kaylor is also targeting another undervalued player who could explode for huge numbers for Thursday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor's TNF DFS picks, at SportsLine

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Thursday Night Football, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament, and find out.