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The Florida Gators and Missouri Tigers are set to square off in an SEC battle at 3 p.m. ET on Wednesday at Mizzou Arena. Florida has won four of its last six games, while Missouri has lost five of its last six. The Gators have won six of the last nine meetings against the Tigers. 

The Gators are favored by 5.5-points in the latest Missouri vs. Florida odds from Caesars Sportsbook, and the over-under is set at 135. Before entering any Florida vs. Missouri picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Missouri vs. Florida. You can head to SportsLine to see its picks. Here are several college basketball odds for Florida vs. Missouri:

  • Missouri vs. Florida spread: Missouri +5.5
  • Missouri vs. Florida over-under: 135 points

What you need to know about Missouri

The contest between the Tigers and the Iowa State Cyclones this past Saturday was not a total blowout, but with Mizzou falling 67-50 on the road, it was darn close to turning into one. The top scorer for Mizzou was guard DaJuan Gordon (15 points) and he also led the team with seven rebounds.

The Kansas State transfer is averaging 8.8 points and 4.4 rebounds per game in his first season on campus. Rebounding will be key for the Tigers on Wednesday, as they're -25 on the boards during a current three-game losing streak. Cuonzo Martin's squad will need to body up against a Florida squad that has some size and length in its rotation.

What you need to know about Florida

Meanwhile, Florida picked up an 81-72 win over the Oklahoma State Cowboys this past Saturday. The Gators got double-digit scoring from four players: guard Tyree Appleby (21), guard Phlandrous Fleming Jr. (14), guard Kowacie Reeves (11), and forward Anthony Duruji (10).

Florida was without starting center Colin Castleton in the victory and the big man is expected to miss Wednesday's contest as well with a shoulder injury. Castleton leads the team in scoring (15.4 ppg) and rebounding (9.1 rpg) this season and his productivity will be sorely missed.

How to make Florida vs. Missouri picks

The model has simulated Missouri vs. Florida 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Missouri vs. Florida? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.