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The 20th-ranked Florida State Seminoles will look for payback when they take on the Indiana Hoosiers in a rematch from last year's ACC/Big Ten Challenge matchup on Wednesday. Indiana won last year's game by 16 points. Neither team, however, has done very well in this event all-time. The Hoosiers are 8-11 overall in the event, while the Seminoles are 9-12. Florida State, however, is 6-5 in ACC/Big Ten Challenge games at home.

The game is slated to begin at 7:15 p.m. ET from Tucker Center in Tallahassee, Fla. Indiana is averaging 72.8 points per game, while Florida State scored 86 in its lone game of the season. The Seminoles are 3.5-point favorites in the latest Indiana vs. Florida State odds from William Hill Sportsbook, while the over-under for total points scored is set at 140. Before making any Florida State vs. Indiana picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,700 for $100 players on its top-rated college basketball picks against the spread. It's also off to a fast start in the 2020-21 season, going 5-1 on all its top-rated picks and returning over $400. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Indiana vs. Florida State in the ACC/Big Ten Challenge 2020. You can visit SportsLine now to see the picks. Here are the college basketball lines from William Hill and trends for FSU vs. Indiana:

  • Indiana vs. Florida State spread: FSU -3.5
  • Indiana vs. Florida State over-under: 140 points
  • Indiana vs. Florida State money line: Indiana +145, FSU -170
  • IU: Is 3-0 when leading at halftime this season
  • FSU: The Seminoles are 66-3 (.957) in their last 69 home games since the end of the 2015-16 season

Why Florida State can cover

The Seminoles, who were 16-0 on their home court last year, have won 39 consecutive non-ACC home games. They have a number of scorers, including freshman Scottie Barnes, who was chosen as the Preseason ACC Freshman of the Year by the media. Barnes scored eight points and grabbed six rebounds in an 86-58 win over North Florida on Dec. 2. He is on the Preseason Naismith Award Player of the Year and the Preseason Wooden Award Player of the Year Watch Lists.

Junior forward RaiQuan Gray is also off to a good start to his season. Against North Florida, Gray scored eight points, grabbed five rebounds and added four steals. He is hitting 50 percent of his shots from the floor. He is one of the team leaders, starting 24 games last season and has 28 career starts.

Why Indiana can cover

The Hoosiers are led by sophomore Trayce Jackson-Davis, who has been red-hot to start the season. He is averaging 21.5 points and seven rebounds per game, and is hitting 50.8 percent of his shots from the floor. In the third-place game of the Maui Invitational, Jackson-Davis led the Hoosiers with 31 points and six rebounds as Indiana rolled to a 79-63 win over Stanford. Last year, he finished second in the Big Ten Conference in field goal percentage at 56.6 and seventh in rebounding at 8.4.

Also giving the offense a boost is junior forward Race Thompson, who is hitting 60.7 percent of his shots from the floor. Thompson is third on the Hoosiers in scoring at 11.5 points per game and is averaging 7.5 rebounds, 1.8 assists and two blocks per game. As a redshirt sophomore in 2019-20, he became a key contributor in the second half of the season, averaging 4.8 points and 4.7 rebounds. Thompson was second on the team with 19 blocked shots and 20 steals.

How to make Indiana vs. Florida State picks

SportsLine's model is leaning under on the total, with both teams projected to have just one player score double-digits. The model also says one side of the spread hits in well over 70 percent of simulations. You can only get the pick at SportsLine

So who wins Florida State vs. Indiana? And which side of the spread cashes in well over 70 percent of simulations? Visit SportsLine now to see which side of the Indiana vs. FSU spread to jump on, all from the advanced model that is up almost $2,700 on its top-rated college basketball spread picks over the past four-plus years, and find out.