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The Saint Louis Billikens will take on the Mississippi State Bulldogs at 5 p.m. ET on Saturday in a 2021 National Invitational Tournament first-round matchup at Comerica Center. MSU is 15-14, while the Billikens are 14-6. The winner will play Richmond (14-8) in the second round of the NIT bracket on Thursday.

The Billikens are favored by 4.5 points in the latest Saint Louis vs. Mississippi State odds from William Hill Sportsbook, and the over-under is set at 135. Before entering any Mississippi State vs. Saint Louis picks, you'll want to see the NIT predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,500 for $100 players on its top-rated college basketball picks against the spread. It has also returned almost $500 on all top-rated college basketball picks this season. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Saint Louis vs. Mississippi State in the 2021 NIT. You can head to SportsLine to see its picks. Here are several college basketball odds for Mississippi State vs. Saint Louis:

  • Saint Louis vs. Mississippi State spread: Saint Louis -4.5
  • Saint Louis vs. Mississippi State over-under: 135 points
  • Saint Louis vs. Mississippi State money line: St. Louis -200 Mississippi State +170  

What you need to know about Saint Louis

The Billikens are making their 19th NIT appearance. They last played in the tourney in 2004. Saint Louis was ousted from the Atlantic 10 tournament by conference champion St. Bonaventure in the semifinals, 71-53. The Billikens have a 19-17 all-time record in the NIT. 

Javonte Perkins (17 points per game) and guard Jordan Goodwin (14.5) lead the Billikens in scoring. Yuri Collins ranked No. 9 in the nation with 6.2 assists per game. He had nine assists against St, Bonaventure. Saint Louis is 1-1 all-time vs. Mississippi State

What you need to know about Mississippi State

The Bulldogs reached the NIT semifinals in their last appearance in 2017-18. This is their 10th appearance in the tournament. Mississippi State took an 85-48 loss against conference champion Alabama in the SEC quarterfinals. D.J. Stewart Jr. finished with only four points on 2-for-14 shooting and turned the ball over seven times in his 33 minutes on the court.

Mississippi State has only two seniors and 13 underclassmen on its roster. Iverson Molinar leads the Bulldogs in scoring 16.6 points per game. Tolu Smith averages 12.7 points and 8.5 rebounds per game. The Bulldogs have won four of their last five NIT openers. 

How to make Mississippi State vs. Saint Louis picks

The model has simulated Saint Louis vs. Mississippi State 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Saint Louis vs. Mississippi State? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the Saint Louis vs. Mississippi State spread to jump on Saturday.