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The No. 11-seed Notre Dame Fighting Irish and the No. 14-seed Wake Forest Demon Deacons are set to square off in a 2021 ACC Tournament first-round matchup at 7 p.m. ET on Tuesday at Greensboro Coliseum. Wake Forest is 6-15, while the Fighting Irish are 10-14. Notre Dame won the last meeting on Feb. 2, 79-58. 

The Fighting Irish are favored by eight points in the latest Notre Dame vs. Wake Forest odds from William Hill Sportsbook, and the over-under is set at 141. Before entering any Wake Forest vs. Notre Dame picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,600 for $100 players on its top-rated college basketball picks against the spread. It has also returned over $400 on all top-rated college basketball picks this season. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Wake Forest. You can head to SportsLine to see its picks. Here are several college basketball odds for Wake Forest vs. Notre Dame:

  • Notre Dame vs. Wake Forest spread: Notre Dame -8
  • Notre Dame vs. Wake Forest over-under: 141 points

What you need to know about Notre Dame

Notre Dame upended the Florida State Seminoles this past Saturday, 83-73. Five players scored in double digits: Prentiss Hubb (22 points), Dane Goodwin (15), Nikola Djogo (11), Nate Laszewski (11), and Cormac Ryan (11). It was the Fighting Irish's first ranked win since 2017. Notre Dame stopped a four-game losing streak with the victory. 

Hubb is 10th in the nation in total assists (145) and 14th in assists per game (6.0). Notre Dame has won four of five ACC tournament games at Greensboro Coliseum. The Fighting Irish have won their first game in the ACC tourney in 11 of the last 12 seasons. 

What you need to know about Wake Forest

Wake Forest lost to the Georgia Tech Yellow Jackets at home on Friday, 75-63. The Demon Deacons allowed the Yellow Jackets to shoot 55.8 percent from the field. Ian DuBose scored 18 points. Wake Forest has lost seven consecutive games. 

Daivien Williamson scored 15 points on Friday. The Demon Deacons last made it to the second round of the ACC tourney in 2017. Wake Forest has lost seven of 12 all-time matchups with Notre Dame. 

How to make Notre Dame vs. Wake Forest picks

The model has simulated Notre Dame vs. Wake Forest 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Notre Dame vs. Wake Forest? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to see which side of the Notre Dame vs. Wake Forest spread to jump on Tuesday