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Two of the nation's top offenses could light up the afternoon when the top-ranked Alabama Crimson Tide host the No. 12 Ole Miss Rebels in Saturday's SEC on CBS matchup. The Crimson Tide (4-0) passed their first test when they edged then-No. 11 Florida 31-29 two weeks ago. Quarterback Bryce Young and a stout defense give Tide fans hope for another banner year, and Bama has won five straight against the Rebels. Ole Miss (3-0) is led by Matt Corral, who is the +180 co-favorite along with Young in the Heisman Trophy race, according to Caesars Sportsbook. He leads a Rebels offense that averages an FBS-best 52.6 points, while Bama ranks fourth at 46.5.

Kickoff is set for 3:30 p.m. ET in Tuscaloosa, Ala. The Crimson Tide are the 15-point favorites in the latest Ole Miss vs. Alabama odds from Caesars, and the over-under for total points scored is set at 79.5. Before locking in any Alabama vs. Ole Miss picks, make sure to check out the college football predictions and analysis from the proven SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on a 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has locked in on Alabama vs. Ole Miss and just revealed its picks and predictions. You can head to SportsLine now to see the model's picks. Here are the betting lines and trends for Ole Miss vs. Alabama:  

  • Mississippi vs. Alabama: Crimson Tide -15 
  • Mississippi vs. Alabama over-under: 79.5 points 
  • Mississippi vs. Alabama moneyline: Rebels +475, Crimson Tide -700 
  • MISS: The Rebels are 5-0 ATS in their last five as road underdogs
  • ALA: The Crimson Tide are 13-8 ATS as home favorites since 2018
Featured Game | Alabama Crimson Tide vs. Ole Miss Rebels

Why Alabama can cover

Alabama has already faced a big game, and this is the biggest one the Rebels have seen in a long time. The Tide also will have a sea of red behind them and have a clear edge on defense. They allow averages of 17.5 points (27th in FBS) and 283.8 yards (17th) and have taken the ball away seven times. Six players have interceptions, and the linebacking corps is considered the best in the nation. The Rebels, meanwhile, rank outside the FBS top 50 in total yardage (344.7, 59th), passing (208.5, 53rd) and rushing (136, 61st) and are 50th in scoring (20.7).

The Alabama offense has plenty of ways it can exploit that defense, with Young having a wealth of talent around him. The sophomore is completing more than 72 percent of his attempts and has 1,124 yards, 15 TDs and just one interception. Wideouts Jameson Williams (24.9 yards per catch, three TDs) and John Metchie III (team-high 24 catches) are both downfield threats, while tight ends Jahleel Billingsley (21.8 per catch) and Cameron Latu (four TDs) give Young even more options. Running back Brian Robinson Jr. (208, two TDs) can keep the Rebels off balance.     

Why the Ole Miss can cover

Ole Miss has enviable balance on offense, leading the nation in total yards (653.3 per game) and ranking fourth in rushing (298.7). Corral has been in the center of it all, throwing for 997 yards and no interceptions and rushing for 158 yards, accounting for 14 total touchdowns. He gets help from backfield mates Jerrion Ealy (188 yards) and Henry Parrish Jr. (176). The Rebels average 6.2 per carry as a team, and Snoop Conner (three TDs) can get the tough yardage. They face a Bama defense that allowed 244 yards on the ground in its win against Florida.

If the run isn't working, Corral can air it out to big-play wideouts Dontario Drummond (339 yards, four TDs) and Braylon Sanders (16.6 per reception, three TDs), and Ealy has 78 receiving yards out of the backfield. The Rebels defense has been average so far, but end Sam Williams is expected to be a first-round NFL draft pick. He has four sacks, a pass defended and two forced fumbles already. The underdog is 5-2 against the spread in the last seven meetings between these teams.

How to make Mississippi vs. Alabama picks

The model is projecting under on the point total, suggesting the teams will combine for 73 points. It also has generated a point-spread pick that is hitting in 60 percent of simulations. You can only get the model's Alabama vs. Ole Miss picks at SportsLine

So who wins the Mississippi vs. Alabama matchup on Saturday? And which side of the spread is hitting 60 percent of the time? Visit SportsLine right now to see which side of the Alabama vs. Mississippi spread to back Saturday, all from the advanced model on an 81-61 run on its top-rated college football picks, and find out.