The Missouri Tigers will make their first-ever appearance at Jordan-Hare Stadium when they take on the Auburn Tigers in a Southeastern Conference crossover matchup on Saturday in Auburn, Ala. Missouri (2-1) was 3-5 in the SEC-East and 6-7 overall in 2021, while Auburn (2-1) was 3-5 in the SEC-West and 6-7 overall. After losing 40-12 to Kansas State in Week 2, Missouri bounced back for a 34-17 win over Abilene Christian last week. Auburn is coming off a 41-12 loss to Penn State in Week 3.

Kickoff is set for noon ET. Missouri is averaging 32.7 points per game this season, while Auburn averages 26.0. Auburn is favored by 7.5 points in the latest Missouri vs. Auburn odds from Caesars Sportsbook, while the over/under for total points scored is 51. Before making any Auburn vs. Missouri picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Missouri vs. Auburn and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Auburn vs. Missouri:

  • Missouri vs. Auburn spread: Auburn -7.5
  • Missouri vs. Auburn over/under: 51 points 
  • Missouri vs. Auburn money line: Missouri +228, Auburn -285
  • MIZ: The under is 4-0 in Missouri's last four games against a team with a winning record  
  • AUB: Auburn is 6-1 against the spread in their last seven games following a double-digit loss at home 
  • Missouri vs. Auburn picks: See picks here
Featured Game | Auburn Tigers vs. Missouri Tigers

Why Auburn can cover

Auburn has had a lot of success in conference openers. Auburn is 51-32-5 (.608) all-time and 24-5 over the last 29 SEC opening games, including a 24-19 win at LSU last season. In SEC home openers, Auburn is 57-26-2 (.682) all-time, including a 34-10 loss to Georgia last season. Since 1933, Auburn has compiled a 333-262-18 league mark, including 142-64-6 in SEC games played at Auburn.

Junior wide receiver Ja'Varrius Johnson is off to a good start to the season. He has a team-leading 13 receptions for 231 yards (17.8 average), including a long of 56 yards. In last week's 41-12 loss to Penn State, Johnson caught six passes for 73 yards, including a long of 24 yards. For his career, he has 32 receptions for 505 yards (15.8 average) and two touchdowns. He has also rushed for one.

Why Missouri can cover 

Sixth-year wide receiver Barrett Banister is off to another solid start with 10 receptions for 105 yards. Banister has played in 47 career games and has hauled in 27 or more receptions in three consecutive seasons. He's made catches in six consecutive games, dating back to Florida in 2021, and three in each of the first three games of 2022. Against Abilene Christian, Banister had four catches for 44 yards, surpassing 100 career receptions. He's the 25th Missouri player to hit the milestone, and has 102 catches for 912 yards and two touchdowns.

If the game comes down to a late field goal or extra point, Missouri kicker Harrison Mevis is a proven clutch performer. Mevis connected on a 52-yard field goal in the fourth quarter last week against Abilene Christian. It was his seventh 50-yard field goal of his career. Mevis has made 45 field goals in his career, good for fifth all-time, and his 19 field goals from at least 30 yards out last year are the most by a returning kicker in 2022. Mevis was 23-for-25 on field goals for 92 percent and totaled 109 points a year ago, taking sole possession of ninth on the Missouri all-time single-season scoring list.

How to make Missouri vs. Auburn picks

SportsLine's model is leaning Over the total, projecting 57 combined points. It has also generated an against the spread pick that cashes in more than 50% of simulations. You can only get the model's pick at SportsLine

So who wins Missouri vs. Auburn? And which side of the spread cashes in more than 50% of simulations? Visit SportsLine now to see which side of the Missouri vs. Auburn spread to jump on, all from the advanced model that finished the past six-plus years up more than $3,300 on its FBS college football picks, and find out.