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Clemson (7-3, 5-2 ACC) hasn't lost since dropping its third game of the season to No. 20 Pittsburgh on Oct. 23, and it will face the ACC's top team this weekend. The Tigers will host No. 10 Wake Forest (9-1, 6-0) at Memorial Stadium on Saturday. The Demon Deacons sit atop the ACC standings and have only lost one game in 2021. They will clinch the ACC Atlantic division title with a win. Clemson's stagnant passing attack pales in comparison to Wake Forest's ahead of this matchup, but oddsmakers expect a one-score game. 

Kickoff is set for noon ET. The latest Wake Forest vs. Clemson odds from Caesars Sportsbook list the Tigers at -4, while the over-under for total points is set at 57. Before finalizing any Clemson vs. Wake Forest picks, be sure to see the college football predictions and betting advice from SportsLine's proven model

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Wake Forest vs. Clemson and locked in its picks and predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Clemson vs. Wake Forest:

  • Wake Forest vs. Clemson spread: Clemson -4
  • Wake Forest vs. Clemson over-under: 57 points 
  • Wake Forest vs. Clemson money line: Clemson -175, Wake Forest +150
  • WAKE: The over has hit in six of the Demon Deacons' last seven games 
  • CLEM: The Tigers are 5-0 straight up in their previous five home games against the Demon Deacons
Featured Game | Clemson Tigers vs. Wake Forest Demon Deacons

Why Wake Forest can cover

Only three FBS teams have more wins than Wake Forest in 2021. The Demon Deacons are 2-2 against the spread on the road and have only lost 58-55 to North Carolina in a game that didn't count in the conference standings. Few teams can match their aerial attack, and Clemson has had its fair share of struggles throwing the football.

Wake Forest quarterback Sam Hartman has tormented opposing defenses in 2021. He's rushed for 328 yards and nine scores in addition to tallying 3,163 passing yards with 30 touchdowns and eight interceptions. Hartman's skill set has helped the Demon Deacons score at least 40 points in five consecutive games. Clemson has begun to iron out its kinks on offense, but DJ Uiagalelei's performance remains inconsistent. Wake Forest's consistency could give the visitors an edge.

Why Clemson can cover

The Tigers have bounced back after a slow start to the season. They've won three straight contests ahead of Week 12. Clemson's last two home wins have been by double-digits. Clemson's passing attack has struggled, but it has enough talent in the backfield to dominate Wake Forest's subpar run defense.

Wake Forest's front line has been dominated opposing running backs in three consecutive road games. Syracuse, Army, and North Carolina racked up more than 300 rushing yards apiece against the Demon Deacons. Clemson could control the clock if it has similar success on the ground. The Tigers don't have a dominant feature back but have had a 100-yard rusher in two of their previous three home games.

How to make Wake Forest vs. Clemson picks

SportsLine's model is leaning under on the total. It also has generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the model's Clemson vs. Wake Forest picks at SportsLine.

So who wins Wake Forest vs. Clemson? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has crushed its college football picks, and find out.