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Lane Kiffin and the No. 9 Ole Miss Rebels aim to keep things rolling on Saturday afternoon. Ole Miss is 6-0 overall to begin the 2022 season, including a 2-0 mark in SEC play following a 52-28 win over Vanderbilt. The Rebels host the Auburn Tigers in an SEC West matchup that doubles as the seventh game of the season for both sides. Auburn is 3-3 overall and 1-2 in SEC play under Bryan Harsin this season.

Kickoff is set for noon ET. Caesars Sportsbook lists the Rebels as 15.5-point home favorites. The total number of points Vegas thinks will be scored, or the over/under, is 55.5 in the latest Auburn vs. Ole Miss odds. Before locking in any Ole Miss vs. Auburn picks and college football predictions, see what SportsLine's advanced computer model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Auburn vs. Ole Miss and just locked in its picks and CFB predictions. You can visit SportsLine now to see its picks. Here are the college football odds and betting lines for Ole Miss vs. Auburn:  

  • Auburn vs. Ole Miss spread: Ole Miss -15.5
  • Auburn vs. Ole Miss over/under: 55 points
  • Auburn vs. Ole Miss money line: Ole Miss -700, Auburn +500
  • AUB: The Tigers are 1-5 against the spread this season
  • MISS: The Rebels are 3-3 against the spread this season
  • Auburn vs. Ole Miss picks: See picks at SportsLine
Featured Game | Ole Miss Rebels vs. Auburn Tigers

Why Auburn can cover

Auburn has enjoyed success against Ole Miss in a broad sense. The Tigers are 35-10 all-time against the Rebels, including a 12-2 mark in Oxford. Auburn is on a six-game winning streak in the series, including a 31-20 win in 2021, and the Tigers have scored at least 30 points in five of the last six meetings. Auburn's offense relies on the running game, with a dual-threat quarterback in Robby Ashford producing 275 rushing yards from the position. 

Standout running back Tank Bigsby rushed for nearly 1,100 yards in 2021, and he has more than 430 total yards and four touchdowns in 2022. On defense, Auburn is holding opponents to a completion rate below 60% and only 6.5 yards per pass attempt this season. Opponents have only two passing touchdowns against Auburn this season, and senior linebacker Derick Hall creates havoc. Hall has four sacks, 30 total tackles, and an interception in 2022 after a nine-sack performance during the 2021 season.

Why Ole Miss can cover 

Ole Miss is 6-0 for the first time since 2014 and 16-3 since the beginning of the 2021 season. That marks trails only Alabama and Georgia among SEC teams, and the Rebels are excelling on both offense and defense. Ole Miss is averaging 39.7 points and 490.3 total yards per game, including a dominant rushing attack. The Rebels have the most rushing touchdowns (21) in the SEC, with 5.6 yards per carry and 242.0 rushing yards per game. Ole Miss is also leading the conference with a 53.3% third down conversion rate, and the defense is giving up only 14.5 points per game. 

That ranks in the top 12 of FBS, and Ole Miss is yielding only 330.2 total yards and 117.8 rushing yards per game. The Rebels are giving up only 3.1 yards per carry and 6.2 yards per pass attempt to opponents, and Ole Miss has 16 sacks in six games. With Auburn posting SEC-worst marks in scoring offense, completion rate, and third down conversion rate, the Rebels project to be in a very strong position at home in Oxford.

How to make Auburn vs. Ole Miss picks

SportsLine's model is leaning Under on the total, with neither team projected to reach 250 passing yards. The model also says one side of the spread hits in well over 50% of simulations. Head to SportsLine to see the picks

So who will win Ole Miss vs. Auburn? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the model that has crushed its college football picks, and find out.