South Carolina will try to build on momentum from the end of last season when the Gamecocks face No. 21 North Carolina on Saturday night in the 2023 Duke's Mayo Classic. The Gamecocks posted back-to-back top-10 wins over Tennessee and Clemson last year before losing to Notre Dame by a touchdown in the Gator Bowl. UNC lost its final four games after getting off to a 9-1 start, falling to Oregon in the Holiday Bowl. South Carolina won the most recent contest between these teams in a 38-21 final at the Duke's Mayo Bowl in 2021.

Kickoff is set for 7:30 p.m. ET at Bank of America Stadium in Charlotte. The latest North Carolina vs. South Carolina odds via the SportsLine consensus list the Tar Heels as 2.5-point favorites, with the over/under at 63.5, up two points from the opening line. Before entering any North Carolina vs. South Carolina picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on North Carolina-South Carolina. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • South Carolina vs. North Carolina spread: UNC -2.5
  • South Carolina vs. North Carolina over/under: 63.5 points
  • South Carolina vs. North Carolina money line: South Carolina: +114, North Carolina: -137
  • South Carolina vs. North Carolina picks: See picks here

Why North Carolina can cover

North Carolina returns ACC Player of the Year Drake Maye, who threw for 4,321 yards, 38 touchdowns and seven interceptions in his first season as the starter. Maye, who also led the team with 698 rushing yards and seven scores, is projected to be a top pick in next year's draft. He helped the Tar Heels get off to a hot start last year, and they hold a 35-20-4 edge in the all-time series between these schools.

South Carolina needs a better effort from a run defense that allowed almost 200 yards per game last season, and it is facing a North Carolina offensive line that returns four senior starters. The Gamecocks have lost six of their last eight games against ACC teams, and they have only covered the spread twice in their last six September games. The betting line has moved toward North Carolina, despite more public bets being placed on the Gamecocks, suggesting that sharp money is on the Tar Heels. 

Why South Carolina can cover

South Carolina has been red-hot in season openers in recent years, winning 15 of its last 17 games in Week 1. The Gamecocks have covered the spread in six of their last eight Saturday games. Meanwhile, North Carolina has only covered the spread twice in its last 10 season openers and is 1-5 against the spread in its last six games against SEC teams. 

The Tar Heels struggled at the end of the 2022 campaign, averaging just 20.2 points during their final four games. They lost star wide receiver Josh Downs to the NFL, while Rattler returns Antwane Wells Jr., who finished with the second-most receiving yards in the SEC last year. South Carolina enters the year with momentum after springing outright upsets against Tennessee and Clemson. See which team to pick here. 

How to make South Carolina vs. North Carolina picks

The model has simulated North Carolina vs. South Carolina 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits in more than 50% of simulations. You can only see the pick at SportsLine.

So who wins South Carolina vs. North Carolina, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the North Carolina vs. South Carolina spread to jump on, all from the advanced computer model that's up nearly $2,500 on its top-rated college football spread picks since its inception, and find out.