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The UCLA Bruins (6-4) and the USC Trojans (7-4) are set to square off in a rivalry battle on Saturday afternoon. UCLA has lost two straight games to teams from Arizona, including a 17-7 setback against Arizona State last week. The Bruins have only picked up one road win since September, which came at Stanford a month ago. USC has dropped four of its last five games, falling in back-to-back contests against Washington and Oregon to open November. 

Kickoff is set for 3:30 p.m. ET on Saturday at United Airlines Field at the Los Angeles Memorial Coliseum. The Trojans are favored by 6.5 points in the latest USC vs. UCLA odds, while the over/under is set at 65.5 points, per SportsLine consensus. Before entering any UCLA vs. USC picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a strong profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on UCLA-USC. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • USC vs. UCLA spread: USC -6.5
  • USC vs. UCLA over/under: 65.5 points
  • USC vs. UCLA money line: USC: -257, UCLA: +208
  • USC vs. UCLA picks: See picks here
  • USC vs. UCLA live stream: fubo (try for free)

Why USC can cover

USC is coming off a pair of losses to College Football Playoff contenders in Washington and Oregon, but the Trojans were competitive in both outings. They stayed within single digits against the Ducks, covering the 16.5-point spread. Reigning Heisman Trophy winner Caleb Williams is tied with Oregon's Bo Nix for the second-most passing touchdowns in the country this season (29), and he has also rushed for an additional 11 scores. 

UCLA is coming off back-to-back double-digit losses to Arizona and Arizona State, generating a combined 17 points of offense in those games. Freshman quarterback Dante Moore did not play against the Sun Devils, and he is questionable for this contest. The Bruins had three straight possessions deep in Arizona State territory that did not end with any points. 

Why UCLA can cover

This is a perfect opportunity for UCLA to fix some offensive issues, as USC's defense is among the worst in college football. The Trojans have allowed at least 34 points in each of their last seven games, leading to the dismissal of defensive coordinator Alex Grinch before last week's game against Oregon. They did not show much improvement, allowing passing touchdowns of 77 and 84 yards. 

The Trojans are also officially eliminated from Pac-12 title contention, so their motivation could be low heading into this contest. UCLA has been solid defensively, allowing 30 points just one time this season, which came in a loss at Oregon State in October. USC has only covered the spread once in its last eight games, making the Trojans a team to avoid. See which team to pick here. 

How to make USC vs. UCLA picks

The model has simulated UCLA vs. USC 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that has is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins USC vs. UCLA, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the UCLA vs. USC spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.