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An interleague battle gets underway Saturday evening when the New York Yankees (42-16) host the Chicago Cubs (23-34). These teams are playing like complete opposites right now. The Cubs have dropped five of their last six games. On the flip side, New York is 8-1 over its last nine games. The Yankees beat the Cubs 2-1 in the first game of the series. Jordan Montgomery (1-1, 3.02 ERA) is on the mound of New York. Matt Swarmer (1-0, 1.50 ERA) gets the start for Chicago.

First pitch is set for 7:15 p.m. ET. Caesars Sportsbook lists New York as the -240 favorite on the moneyline (risk $240 to win $100) in the latest Yankees vs. Cubs odds. Chicago is the +200 underdog and the over-under for total runs expected is nine. Before finalizing any Yankees vs. Cubs picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 52-37 roll on top-rated MLB money-line picks through nine weeks, returning over $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Yankees vs. Cubs, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for Cubs vs. Yankees:

  • Cubs vs. Yankees moneyline: New York -240, Chicago +200
  • Cubs vs. Yankees run-line: New York -1.5 (-115)
  • Cubs vs. Yankees over-under: 9 runs
  • Cubs vs. Yankees tickets: See tickets at StubHub
  • NYY: Yankees are 7-1 in their last eight interleague games as favorites
  • CHC: Cubs are 8-2 in their last 10 interleague road games vs. a left-handed starter
Featured Game | New York Yankees vs. Chicago Cubs

Why you should back the Yankees

First baseman Anthony Rizzo generates power and can drive in runs with consistency for New York. Rizzo has a big frame and at times will be aggressive at the plate. The three-time All-Star does need to cut down his strikeouts and look to hit for a better average, who Rizzo is second on the team in home runs (14) and RBIs (39).

Outfielder Aaron Hicks is a superb athlete with unbelievable range on the defensive end. Hicks owns a strong arm with solid speed. The 32-year-old currently has two homers and 11 RBIs. Hicks has logged two-plus hits in three of his last four games. On June 9, he went 2-for-5 with a two-run homer and three total RBIs. 

Why you should back the Cubs

Center fielder Ian Happ is a switch-hitter with power potential. He has great knowledge of the strike zone and won't go chasing pitches. The 27-year-old will walk a lot and is a versatile defender. Happ's batting average is .267 with six home runs and 29 RBIs. He is currently on a nine-game hitting streak.

Willson Contreras is a good athlete behind the plate. Contreras is a high-energy player with a solid throwing arm. The two-time All-Star is a sound hitter with strong pitch recognition skills. He's hitting .273 with 10 long balls and 23 RBIs. Contreras has recorded a hit in four straight games. 

How to make Cubs vs. Yankees picks

SportsLine's model is leaning over on the total, projecting 9.1 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Yankees vs. Cubs? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.