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A first-round Eastern Conference showdown in the 2022 NBA playoffs features the fourth-seeded Philadelphia 76ers going on the road to take on the fifth-seeded Toronto Raptors in Game 3 on Wednesday night. The 76ers jumped out to a quick 2-0 lead, with a 112-97 win on Monday. Toronto went 24-17 at home during the regular season and needs a crucial win in this contest. 

Tip-off from Scotiabank Arena is at 8 p.m. ET. Philadelphia is favored by two-points in the latest 76ers vs. Raptors odds from Caesars Sportsbook, while the over-under for total points scored is 217.5. Before locking in any Raptors vs. 76ers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past three-plus seasons. The model enters the first full week of the 2022 NBA playoffs on a stunning 86-56 roll on all top-rated NBA picks, returning almost $2,400. Anyone following it has seen huge returns.

Now, the model has set its sights on 76ers vs. Raptors, and just revealed its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for Raptors vs. 76ers:

  • 76ers vs. Raptors spread: Philadelphia -2
  • 76ers vs. Raptors over-under: 217.5 points
  • 76ers vs. Raptors money line: Toronto +110, Philadelphia -130
  • PHI: The 76ers are 0-5 ATS in their last five games on the road
  • TOR: The Raptors are 5-0 ATS in their last five Wednesday games

Why the 76ers can cover

Guard James Harden is a regular triple-double threat and can dominate both from the arc and driving to the lane. Harden uses his footwork to create space to either attack the basket or step back for a jumper. The 10-time All-Star is an elite distributor with superb court vision. The 2018 NBA MVP put up 22 points and 14 assists in Philadelphia's Game 1 victory. 

Forward Tobias Harris is another solid scoring option in the front court. Harris can get a bucket at all three levels with ease. The Tennessee product is an overall solid rebounder and ball-handler with a smooth-looking jumper. Harris has tallied 20-plus points in both matchups in this series. In his last contest, the 2011 first-round pick finished with 20 points and 10 rebounds. 

Why the Raptors can cover

Guard Fred VanVleet is a quick and agile playmaker in the backcourt for Toronto. VanVleet is also a gritty defender who consistently gives high effort. The 2022 All-Star is a steady shooter on the outside, forcing teams to account for him on the perimeter. In this series, VanVleet is averaging 19 points, 6.5 assists and two steals per game. In Game 1, he recorded 18 points, six assists, and shot 4-for-7 from deep. 

Forward Pascal Siakam is a long and active presence in the paint for Toronto. Siakam runs the floor well and is a threat for put-back dunks. The 2020 All-Star passes the ball well and shows good basketball IQ. In Game 1, Siakam recorded 24 points, seven assists, and three blocks. Toronto will need these two studs to ball out and help pick up a much-needed victory on Wednesday night.

How to make Raptors vs. 76ers picks

SportsLine's model is leaning over on the point total, projecting 219 combined points. The model also says one side of the spread hits in over 50 percent of simulations. You can only see the model's Raptors vs. 76ers picks at SportsLine.

So who wins 76ers vs. Raptors? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Raptors vs. 76ers spread you need to jump on Wednesday, all from the model that has crushed its NBA picks, and find out.