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On Wednesday, the Detroit Pistons aim to knock off the Chicago Bulls for the first time this season. The Bulls won the first two meetings, though Chicago enters the third matchup on the second night of a back-to-back with travel to Detroit. The Pistons are 15-47 after five straight losses, and Detroit has an 8-22 record at home. Chicago is just 2-7 over its last nine games and sports a 28-34 overall record. Jalen Duren (ankle) and Isaiah Stewart (hip) are out for the Pistons.

Caesars Sportsbook lists the Bulls as 6-point road favorites, and tip-off is scheduled for 7 p.m. ET. The total number of points Vegas thinks will be scored, or the over/under, is 221.5 in the latest Bulls vs. Pistons odds. Before you make any Pistons vs. Bulls picks, you'll want to see the NBA predictions and betting advice from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four-plus seasons. The model enters Week 20 of the 2022-23 NBA season on a stunning 57-30 roll on all top-rated NBA picks this season, returning nearly $2,300. Anyone following it has seen huge returns.

Now, the model has set its sights on Bulls vs. Pistons and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for Pistons vs. Bulls:

  • Bulls vs. Pistons spread: Bulls -6
  • Bulls vs. Pistons over/under: 221.5 points
  • Bulls vs. Pistons money line: Bulls -225, Pistons +185
  • CHI: The Bulls are 5-5-1 against the spread with no rest
  • DET: The Pistons are 12-16-1 against the spread in home games
  • Bulls vs. Pistons pick: See picks at SportsLine

Why the Bulls can cover

Chicago's profile has encouraging signs on both ends of the floor. The Bulls are in the top six of the NBA in both field goal percentage and free throw percentage on offense, with Chicago committing fewer than 14 turnovers per game. Detroit is No. 28 in the league in defensive rating, giving up almost 1.18 points per possession, and the Pistons rank No. 24 or worse in opponent shooting, free throw prevention, and defensive rebound rate.

On the other end, Chicago's defense is tremendous, giving up fewer than 1.12 points per possession. That ranks in the top six in overall efficiency, with Detroit ranking 27th in scoring only 110.3 points per 100 possessions. Chicago is dominant on the defensive glass, posting top-three marks in defensive rebound rate and second-chance points allowed, and Detroit has significant trouble in making shots. The Pistons are shooting only 45.4% from the field and 51.6% on 2-pointers, landing in the bottom five in both areas.

Why the Pistons can cover

Detroit has the benefit of home-court advantage in this matchup, and the Pistons' net rating is 3.1 points better per 100 possessions at home when compared to on the road this season. On offense, the Pistons lead the NBA in free throw creation, averaging 26.8 attempts per game and putting consistent pressure on opponents. Detroit is also in the top 10 of the NBA in both offensive rebound rate (28.9%) and second-chance points (14.9 per game). 

On the other end, Detroit should benefit from Chicago's offensive struggles. The Bulls are No. 24 in the NBA in offensive rating and dead-last in 3-pointers per game. Chicago is also in the bottom five of the league in free throw creation and offensive rebound rate. Detroit is a top-10 team in fast break prevention on defense, and the Pistons also land above the NBA average with 7.2 steals per game this season.

How to make Pistons vs. Bulls picks

SportsLine's model is leaning Over on the total, projecting the teams to combine for 230 points. The model also says one side of the spread hits in well over 50% of simulations. You can only get the pick at SportsLine.

So who wins Bulls vs. Pistons? And which side of the spread hits well over 50% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.