Who's Playing

Arizona @ San Francisco

Current Records: Arizona 7-1; San Francisco 3-4

What to Know

The Arizona Cardinals have enjoyed the comforts of home their last two games, but now they must head out on the road. Arizona and the San Francisco 49ers will face off in an NFC West battle at 4:25 p.m. ET Sunday at Levi's Stadium. San Francisco should still be feeling good after a victory, while the Cardinals will be looking to right the ship.

It was a hard-fought game, but Arizona had to settle for a 24-21 loss against the Green Bay Packers last week. QB Kyler Murray had a pretty forgettable game, throwing two interceptions. Murray ended up with a passer rating of 124.30.

Meanwhile, San Francisco netted a 33-22 win over the Chicago Bears last week. San Francisco can attribute much of their success to RB Elijah Mitchell, who rushed for one TD and 137 yards on 18 carries.

Special teams collected 13 points for the 49ers. K Joey Slye delivered a perfect 4-for-4 game.

The Cardinals are expected to lose this next one by 3. Those burned by picking them against the spread last Thursday might want to keep in mind that the team has not yet dropped back-to-back games against the spread this season.

Arizona is now 7-1 while San Francisco sits at 3-4. A pair of defensive numbers to keep in mind before kickoff: Arizona ranks third in the league when it comes to rushing touchdowns allowed, with only four on the season. As for San Francisco, they enter the matchup with only 214.6 passing yards allowed per game on average, good for fourth best in the NFL.

How To Watch

  • When: Sunday at 4:25 p.m. ET
  • Where: Levi's Stadium -- Santa Clara, California
  • TV: FOX
  • Online streaming: fuboTV (Try for free. Regional restrictions may apply.)
  • Follow: CBS Sports App
  • Ticket Cost: $31.99


The 49ers are a 3-point favorite against the Cardinals, according to the latest NFL odds.

The line on this game has moved quite a bit since it opened, as it started out with the Cardinals as a 2.5-point favorite.

Over/Under: -108

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Series History

Arizona have won ten out of their last 13 games against San Francisco.

  • Oct 10, 2021 - Arizona 17 vs. San Francisco 10
  • Dec 26, 2020 - San Francisco 20 vs. Arizona 12
  • Sep 13, 2020 - Arizona 24 vs. San Francisco 20
  • Nov 17, 2019 - San Francisco 36 vs. Arizona 26
  • Oct 31, 2019 - San Francisco 28 vs. Arizona 25
  • Oct 28, 2018 - Arizona 18 vs. San Francisco 15
  • Oct 07, 2018 - Arizona 28 vs. San Francisco 18
  • Nov 05, 2017 - Arizona 20 vs. San Francisco 10
  • Oct 01, 2017 - Arizona 18 vs. San Francisco 15
  • Nov 13, 2016 - Arizona 23 vs. San Francisco 20
  • Oct 06, 2016 - Arizona 33 vs. San Francisco 21
  • Nov 29, 2015 - Arizona 19 vs. San Francisco 13
  • Sep 27, 2015 - Arizona 47 vs. San Francisco 7