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The Kansas City Chiefs will take on the New Orleans Saints at 4:25 p.m. ET on Sunday at Mercedes-Benz Superdome. The Chiefs are 12-1 overall and 7-0 on the road, while New Orleans is 10-3 overall and 5-1 at home. Kansas City has clinched the AFC West title. The Saints have clinched a playoff berth and can wrap up the NFC South title with a win. 

Kansas City is favored by three points in the latest Chiefs vs. Saints odds from William Hill Sportsbook, and the over-under is set at 52.5. Before entering any Chiefs vs. Saints picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 22-11 on top-rated NFL picks this season, returning over $800. The model also enters Week 15 on an incredible 118-76 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Chiefs vs. Saints. You can head to SportsLine to see its picks. Here are several NFL betting lines for Saints vs. Chiefs:

  • Chiefs vs. Saints spread: Chiefs -3
  • Chiefs vs. Saints over-under: 52.5 points
  • Chiefs vs. Saints money line: New Orleans +130, Kansas City -150

What you need to know about the Chiefs

Kansas City beat Miami 33-27 in Week 14, The Chiefs have won eight consecutive games, the fifth-longest winning streak in franchise history. Patrick Mahomes completed 24 of 34 passes for 393 yards and 2 TDs vs. three INTs last week. He only had two INTs prior to the Miami game. Mahomes has 315-plus yards in six straight games, tied for the longest streak in NFL history. He is aiming for his ninth game in a row with a 90-plus rating. Mahomes leads the  NFL with 4,208 pass yards and is the third quarterback in NFL history with 4,000-plus passing yards in three of his first four seasons.

Tyreek Hill had 79 yards and a TD catch and rushed for a 32-yard TD last week, his 14th-career game with two TDs, tied for second-most by a wide receiver in his first five seasons in NFL history. Hill is tied for the NFL lead with 14 receiving TDs. Travis Kelce is aiming for his third game in a row with eight catches, 125 yards and a TD catch. He has 100-plus yards in five of his past six games. Kelce leads all tight ends with 90 catches and 1,250 yards and is tied for the lead with nine TDs. 

What you need to know about the Saints

The Saints saw their nine-game winning streak come to an end as they were upset by the Philadelphia Eagles, 24-21. The loss was the first as a starter for Taysom Hill, who filled in for the past four games for Drew Brees. Hill was sacked five times and the Saints failed to gain 100 yards rushing. Brees (ribs) is expected to return vs. Kansas City.

Michael Thomas has been placed on injured reserve because of an ankle injury. Emmanuel Sanders had his fourth TD catch of the season last week. Alvin Kamara had seven receptions and 94 scrimmage yards with a rushing TD last week. He has seven TDs (six rushing) in his past six games and is aiming for his third game in a row with a rushing TD. Kamara ranks third in the NFL in scrimmage yards (1,422) and is tied for third in scrimmage TDs (14). He leads all running backs with 77 receptions and can become the third running back in NFL history with four seasons of 80-plus catches. 

How to make Chiefs vs. Saints picks

The model has simulated Chiefs vs. Saints 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Chiefs vs. Saints? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the Chiefs vs. Saints spread to jump on Sunday, all from the model that enters Week 15 of the NFL season on an incredible 118-76 roll.