Minnesota Vikings quarterback Kirk Cousins is rarely mentioned among the game's top quarterbacks, but he's thrown for 4,000 yards or more in seven of the last eight seasons and has had at least 25 touchdown passes in every season that he's started at least 10 games. Cousins and the Vikings will host the San Francisco 49ers on Monday Night Football and Cousins enters the matchup as the NFL leader in touchdown passes (14) and as the league's No. 2 passer (1,679 yards). Should you load Cousins into your NFL DFS lineups on Monday Night Football or will Primetime Kirk struggle against the NFL's top scoring defense?

49ers quarterback Brock Purdy was the last pick in the 2022 NFL Draft, but he was thrust into the starting role because of injuries in his rookie season and hasn't looked back. He leads the NFL in QBR (77.0) and is averaging 8.6 yards per pass attempt this season. Having already earned a reputation as a reliable decision maker, he could be one of the more popular options in the NFL DFS player pool. Before locking in any NFL DFS picks for 49ers vs. Vikings on Monday Night Football on sites like DraftKings and FanDuel, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings.

He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments. Last year, he won the DraftKings Millionaire Maker twice and the FanDuel Million once.

Now, McClure has turned his attention to Niners vs. Vikings on Monday Night Football and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for 49ers vs. Vikings

One of McClure's top NFL DFS picks for Monday Night Football is 49ers wide receiver Brandon Aiyuk. Fresh off his first 1,000-yard season, Aiyuk is putting up big numbers yet again with 25 receptions for 454 yards and two touchdowns over five games. Now, he'll take on a Minnesota pass defense that ranks in the bottom half of the league.

He's had a pair of 100-yard outings already this season and figures to play an even more prominent role in the offense with Deebo Samuel (shoulder) unable to play. His 52.3% air yards share leads NFL receivers and he also ranks sixth in the league in target share (31.9%) and target rate (31.4%).

Part of McClure's optimal NFL DFS strategy also includes rostering Vikings running back Alexander Mattison. After four seasons of backing up Dalvin Cook, Minnesota released Cook this offseason and thrust Mattison into the starting role.

Thus far, he's rushed for 320 yards over his first six games and has also caught 18 passes for 104 yards and two touchdowns. He's had double-digit touches in every game this season. That volume is a big reason why you'll want significant exposure to him in your NFL DFS lineups on Monday Night Football. See the rest of McClure's NFL DFS player pool right here.

How to set NFL DFS lineups for Vikings vs. 49ers

McClure is also targeting an undervalued player who is set to explode for huge numbers on Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here. 

So who is Mike McClure putting in his optimal NFL DFS lineups for Monday Night Football? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.