NFL Week 4 betting and fantasy live updates: Latest odds and info on line moves, injuries and more

When Week 4 started, we had 16 games on the slate. Now, we're looking at 15 max, and maybe less. That's because a rash of COVID-19 positive tests in the Titans organization has pushed back their game with the Steelers several weeks, while one positive test on each side of the Patriots-Chiefs matchup has delayed that game at least until Monday or Tuesday, and maybe indefinitely. We know that if the game does go off this week, it'll happen without Cam Newton, who was placed on the COVID-19 reserve list on Saturday. And while Vikings-Texans looks like a go as of Saturday, all it'll take is one positive test from Minnesota on gameday to possibly suspend that matchup as well.

We're here to track all the betting and fantasy angles you need to know in the run up to kickoff of the Sunday slate, including line movements, injury updates, inactive lists, depth chart news, the buzz on the betting market, key information from our partners at William Hill Sportsbook and plenty more.

Here's a look at the odds for each Week 4 game as of 12:50 p.m. ET Sunday:

Chargers at Buccaneers (-7.5), O/U 42.5
Browns at Cowboys (-3.5), O/U 56.5
Cardinals (-3) at Panthers, O/U 52
Seahawks (-4.5) at Dolphins, O/U 55
Ravens (-14) at Washington, O/U 45
Jaguars at Bengals (-1), O/U 49.5
Vikings at Texans (-3.5), O/U 53
Saints (-3) at Lions, O/U 51.5
Giants at Rams (-13.5), O/U 49
Colts (-3) at Bears, O/U 43
Bills (-3) at Raiders, O/U 53
Eagles at 49ers (-9), O/U 45.5
Patriots at Chiefs (-11), O/U 50
Falcons at Packers (-6.5), O/U 56.5

Before you get to the latest buzz, let's make sure you have all the right tools to dominate Week 4:

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That's going to do it for our pregame coverage of fantasy and betting angles for Week 4. Good luck with your picks and lineups!

October 4, 2020, 4:58 PM
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Spreads holding steady before kick

Not much to report over the last 20 minutes. We've seen a little bit of movement in a few totals, including in Saints-Lions and Vikings-Texans, but nothing of more than a half-point, while the point spreads have stayed at their current numbers with about 10 minutes until kickoff.

October 4, 2020, 4:52 PM
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Dolphins continue to pick up steam

The line in Seahawks-Dolphins has blown through the dead number of five, dropping a full point over the last hour to sit at Seahawks -4.5 with about a half-hour until kickoff. Is this as far as it will go, or will the market keep pushing it downward until it hits 4? Functionally, there isn't that much difference between 5.5 and 4.5 since final scores landing on 5 is a rarity, so it is possible we see the steam continue.

October 4, 2020, 4:27 PM
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Bucs line jumps before kickoff

While the Bucs opened as 7.5-point favorites in their matchup against the Chargers, the line has sat at Bucs -7 almost all week. However, in the hour before kickoff, the line jumped back to the opening number, with the Bucs back to being 7.5-point favorites. The Chargers offense has been inconsistent under rookie Justin Herbert, while the Bucs defense is looking like one of the better units in the league. The total has bounced around a little but sits at 42.5 as of now.

October 4, 2020, 4:25 PM
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Monday night movement

A Monday that now has two night games with Patriots-Chiefs landing at 7:05 p.m. ET has seen movement on both lines over the last hour. The Chiefs dropped a half-point to -11, and it'll be interesting to see if it falls any further with Bill Belichick on the other sideline. Falcons-Packers, which is now slated for 8:50 p.m. ET, has dropped to Packers -6.5, surprisingly coming off the 7, where it's sat all week.

October 4, 2020, 4:15 PM
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Seahawks, Ravens lines drop

Two road favorites have seen a bit of movement against them over the last hour, with the Seahawks down to -5 for their matchup against the Dolphins, and the Ravens now -14 for their trip to face Washington. Seattle has struggled to cover the spread in Miami historically, going 2-5 ATS while on the longest possible road trip in the NFL.

October 4, 2020, 4:12 PM
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Panthers inactives: Okung to miss second-straight game

Inactives: QB P.J. Walker, CB Stantley Thomas-Oliver, RB Trenton Cannon, LB Chris Orr, OL Dennis Daley, LT Russell Okung, DT Bravvion Roy

Starting left tackle Russell Okung will miss his second consecutive game on Sunday due to a groin injury. Okung was trending in a positive direction as he was able to practice on a limited basis on Thursday and Friday and was officially listed as questionable. Now, Greg Little and Trent Scott are expected to rotate at the position in his absence. 

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Cowboys inactives: Tyron Smith is back

Inactives: QB Ben DiNucci, S Reggie Robinson, LB Rashad Smith, T Alex Light, DT Neville Gallimore

The Cowboys return their elite blindside protector for Dak Prescott so upgrade all Dallas skill players (who were likely already in your lineup) to begin with. Outside of Smith, the Cowboys are rounding into form from a health standpoint.

October 4, 2020, 3:54 PM
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Seahawks inactives: Chris Carson active

Inactives: CB Quinton Dunbar, CB Neiko Thorpe, S Lano Hill, OL Kyle Fuller, RB Carlos Hyde, S Jamal Adams, LB Jordyn Brooks

Chris Carson will play today after suffering a knee injury last week against Dallas. The running back was trending in a positive direction all week and was a full participant in practice on Friday after limited participation on Wednesday and Thursday. Carson will look to continue the strong start to his 2020 season, particularly in the receiving game where he's already hauled in three touchdowns. 

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Browns inactives: Hunt good to go

Inactives: CB Greedy Williams, LB Tae Davis, G Evan Brown, WR Rashard Higgins, DE Adrian Clayborn

The six players listed as questionable are all cleared to play, including running back Kareem Hunt, who's dealing with a groin injury. Guard Joel Bitonio, defensive end Olivier Vernon and corner Denzel Ward are also good to go. Terrance Mitchell will start in place of Greedy Williams.

October 4, 2020, 3:50 PM
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Texans inactives: Will Fuller good to go

Inactives: WR Keke Coutee, CB Cornell Armstrong, FB Cullen Gillaspia, LB Peter Kalambayi, OT Charlie Heck

After popping up on the injury report briefly earlier this week, Fuller got his injury tag removed ahead of Sunday's game and should be good to go. He will continue to operate as the 1a to Brandin Cooks' 1b in the Houston passing attack.

October 4, 2020, 3:48 PM
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Washington inactives: McLaurin active

Inactives: QB Alex Smith, WR Steven Sims Jr., DB Danny Johnson, LB Cole Holcomb, T Saahdiq Charles, DE Chase Young

Top wideout Terry McLaurin gets the all-clear after all four players listed as questionable on the final injury report avoided the inactive list.

October 4, 2020, 3:47 PM
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Dolphins inactives: Byron Jones out

Inactives: CB Byron Jones, RB/WR Malcolm Perry, S Kavon Frazier, DE Jason Strowbridge, T Adam Pankey 

Byron Jones will miss his second-straight game, which will give Xavien Howard and rookie Noah Igbinoghene extended snaps as they take on Seattle. Last week, Jamal Perry played 33 of his 41 snaps inside in the slot, which could happen once again in Week 4. After battling a non-COVID-related illness this week and being listed as questionable, rookie quarterback Tua Tagovailoa is active. Ryan Fitzpatrick, however, is Miami's starter. 

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Bengals inactives: Still no Atkins

Inactives: K Austin Seibert, WR John Ross, CB Mackensie Alexander, RB Trayveon Williams, LB Logan Wilson, OL Keaton Sutherland, DT Geno Atkins

Atkins continues to be a massive loss for the Bengals defense in the middle. Without Alexander, the Bengals continue to be shorthanded on the defensive front. This should be good news for James Robinson and the entire Jaguars offense.

October 4, 2020, 3:43 PM
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Lions inactives: Trufant, Jones cleared

Inactives: TE Hunter Bryant, OL Logan Stenberg, LB Elijah Lee, CB Chris Jones, S C.J. Moore

The Lions had five players listed as questionable heading into the weekend, but the only one they'll be missing is the rookie tight end Bryant. Corner Desmond Trufant is a big addition to the secondary after getting hurt in Week 1, while the position group will also have Darryl Roberts for depth. Linebacker Christian Jones is also good to go for the defense.

October 4, 2020, 3:43 PM
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Saints inactives: No surprises, but big names out

Inactives: WR Michael Thomas, CB Marshon Lattimore, CB Janoris Jenkins, TE Jared Cook, DE Marcus Davenport, OL Andrus Peat, DT Shy Tuttle

New Orleans already announced that Thomas, Cook, Lattimore, Jenkins and Davenport wouldn't play on Friday, but it is worthy to highlight the number of key starters Sean Payton will be down as he faces off against Detroit. As it relates to Michael Thomas (ankle), he was limited in practice all week so he could be nearing a return as soon as Week 5. 

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Vikings inactives: Boyd out as expected

Inactives: WR Tajae Sharpe, OT Oli Udoh, DT James Lynch, DE Eddie Yarbrough, CB Mike Hughes, CB Kris Boyd

While Hughes was listed as out heading into the weekend, the Vikings held out hope Boyd might be able to go after listing him as doubtful. But the corner is unable to play, as expected, leaving the Vikings shorthanded again at corner.

October 4, 2020, 3:39 PM
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Cardinals inactives: Hopkins active

Inactives: QB Brett Hundley, RB Eno Benjamin, S Chris Banjo, S Budda Baker, LB Devon Kennard, OL Josh Miles, OL Josh Jones

The big news out of Arizona is that DeAndre Hopkins -- originally listed as questionable -- will play today for the Cardinals. Hopkins did not practice all week due to an ankle injury, but is going to give it a go against Carolina. Entering Week 4, Hopkins has 32 receptions for 356 yards and a touchdown to his name.  

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Chargers inactives: Norton out

Inactives: QB Tyrod Taylor, WR Joe Reed, S Jahleel Addae, G Trai Turner, OT Storm Norton, OT Bryan Bulaga, WR Mike Williams

The Chargers knew they would be without key lineman Bulaga and Turner after both were ruled out on Friday, but key reserve Storm Norton is also out after being listed as questionable. Williams and Taylor were also ruled out heading into the weekend.

October 4, 2020, 3:36 PM
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Ravens inactives: Baltimore without elite LT

Inactives: LT Ronnie Staley, WR Chris Moore, QB Trace McSorley, S Geno Stone, DE Derek Wolfe, DT Justin Madubuike

The big news here is that Lamar Jackson and the Ravens will be without their elite blinside protector Ronnie Staley. The only silver lining to losing Stanley is that Washington's key injury on the defensive front (Chase Young, OUT) offset the loss of Staley.

October 4, 2020, 3:35 PM
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Buccaneers inactives: No surprises

Inactives: QB Ryan Griffin, WR Chris Godwin, RB Leonard Fournette, OLB Cam Gill, G Aaron Stinnie, DL Khalil Davis

It was previously announced that both Godwin and Fournette were going to miss this game. Their absences should open up the door for others in the Bucs offense, however. Receiver Scotty Miller, who has already built up a solid rapport with Tom Brady, should see an uptick in targets. With Fournette out, Ronald Jones II should see the bulk of the work in the backfield. Prior to Fournette's arrival, many were pointing to a potential breakout year for Jones. 

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Jaguars inactives: Hauschka out

Inactives: QB Jake Luton, WR Dede Westbrook, K Stephen Hauschka, C Brandon Linder, DT Daniel Ekuale, CB Luq Barcoo, CB Josiah Scott

Hauschka joined the team to take over kicking duties, but he'll miss this week due to injury, leaving former Giants kicker Aldrick Rosas to handle things against the Bengals. Westbrook is back on the inactive list with D.J. Chark healthy.

October 4, 2020, 3:34 PM
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Cowboys, Bengals lines keep moving

Browns-Cowboys keeps fluctuating on Sunday morning, with the line back to Cowboys -3.5 after bouncing back to Cowboys -4 earlier in the day. The Jaguars-Bengals line continues to move in a single direction, however, with the Bengals now down to -1 after dropping from -2.5 to -1.5 earlier this morning.

Inactive lists are about to start coming out, so stick with us for the latest on what you need to know for your fantasy lineups.

October 4, 2020, 3:24 PM
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Patriots-Chiefs line reopens for Monday

Patriots-Chiefs is back on for Monday night after a positive COVID-19 test on each side postponed the game, and William Hill Sportsbook has reopened the matchup at Chiefs -11.5, with a total of 50.5. The line sat at Chiefs -7 all week with the total ranging from 53 to 54, but the news that Cam Newton tested positive and Brian Hoyer will start has added 4.5 points to the line.

October 4, 2020, 3:19 PM
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Seahawks-Dolphins headline total moves

The market is expecting quite a bit of scoring in Miami today, as the total for Seahawks-Dolphins has risen 1.5 points since Saturday evening, sitting now at 55.5. The Seahawks have been naming their point total virtually every week on offense, but their defense has struggled to get stops and is dealing with injuries in the secondary, most notably to safety Jamal Adams. Expect fireworks in Miami today.

Other totals that have moved a half-point since Saturday evening: Chargers-Bucs down to 42, Saints-Lions down to 53.5, Giants-Rams up to 48.5, and Eagles-49ers up to 45.5.

October 4, 2020, 3:05 PM
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Bills line about to move?

After opening Bills -2.5 at the beginning of the week, the line for Bills-Raiders has sat at Bills -3 for most of the week. But the juice on Bills side is up to -125 at William Hill Sportsbook, suggesting it could be close to tipping toward 3.5. Anyone looking to take the Bills will want to get on board now, while Raiders backers may be able to hold off and snag a Raiders +3.5 before kick.

October 4, 2020, 2:59 PM
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Ravens continue rising

The line for Ravens-Washington is at its highest point all week, with the road team now 14.5-point favorites as most bettors expect Lamar Jackson and Co. to crush a floundering Football Team after getting embarrassed on Monday Night Football. The line opened at Ravens -13.5 before quickly dipping to -13, but it has steadily risen throughout the week. With a total of 45, it may be time for bettors to start considering a Washington-Under parlay to maximize their potential winnings should the Washington defense show up.

October 4, 2020, 2:57 PM
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Buyback on Cowboys

After the Cowboys dropped a point on Saturday, the market has bought some of that decline back, as the line is up to Cowboys -4 on Sunday morning. The line sat a half-point higher for most of the week, so it'll be interesting to see if it moves even further or stays at 4 by kickoff.

October 4, 2020, 2:52 PM
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Jaguars gain a point in road matchup

After spending much of the week at Bengals -3, the line for Jaguars-Bengals dropped to Bengals -2.5 earlier this weekend. But the market hasn't stopped moving toward the Jaguars, with the road team now just 1.5-point underdogs and +105 on the moneyline (compared to -125 for the Bengals). It appears bettors are fading a Bengals team coming off a 70-minute marathon tie against the Eagles last week with the Jaguars playing on extra rest after their Thursday loss.

October 4, 2020, 2:50 PM
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SNF steams to 49ers

In a Sunday night matchup of two incredibly banged-up teams, bettors are putting much more faith in the 49ers to keep it rolling rather than the Eagles to turn it around. The line for Sunday Night Football has steamed from 49ers -7.5 as of Saturday evening to 49ers -9 by Sunday morning. Will Nick Mullens and Co. be able to cover the huge number? We'll see if there's any buyback on the Eagles throughout the day.

October 4, 2020, 2:46 PM
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