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The Pittsburgh Steelers will face the Tennessee Titans in an AFC matchup on Thursday Night Football. The Titans (3-4), who are looking for their first road win of the season, are 9-11 on the road since the start of the 2021 season. The Steelers (4-3), who are 2-2 on their home field in 2023, have gone 12-8-1 at Acrisure Stadium in Pittsburgh over the past three seasons. The Steelers have won two of their last three games, while the Titans have dropped two of three. Titans quarterback Ryan Tannehill (ankle) is inactive, giving rookie Will Levis his second NFL start.

Kickoff from Acrisure Stadium in Pittsburgh is set for 8:15 p.m. ET. Pittsburgh is a three-point favorite in the latest Steelers vs. Titans odds, while the over/under for total points scored is 37. Before you make any Titans vs. Steelers picks or Thursday Night Football predictions, you need to see what proven SportsLine expert R.J. White has to say, given his mastery of picks involving Pittsburgh

Over the past seven years White, a CBS Sports fantasy and gambling editor, has gone 376-290-24 (56.5%) in the world's most prestigious football handicapping competition, the Las Vegas SuperContest. He also is SportsLine's No. 1 NFL expert, going 535-450-30 on his against-the-spread NFL picks from 2017-22, returning $3,532 to $100 players. Moreover, White is on an incredible 59-29-4 roll on NFL picks involving the Steelers. Anybody following him is way up. 

Now, White has locked in on Steelers vs. Titans from every angle and just locked in his picks and predictions. You can visit SportsLine now to see his picks. Here are several NFL odds and betting lines for Titans vs. Steelers: 

  • Steelers vs. Titans spread: Pittsburgh -3
  • Steelers vs. Titans over/under: 37 points
  • Steelers vs. Titans money line: Pittsburgh -153, Tennessee +129
  • TEN: Titans are 4-3 against the spread in their last seven games
  • PIT: Steelers are 4-3 ATS this season, including 2-2 at home
  • Steelers vs. Titans picks: See picks at SportsLine

Why the Steelers can cover

Running back Jaylen Warren has been a dual-threat coming out of the backfield. The second-year veteran has rushed for 175 yards on 45 carries (3.9 average) with one touchdown and is second on the team with 26 receptions for 184 yards (7.1 average). He has two explosive plays of 20 or more yards receiving, including a high of 30 yards. Warren has 122 career carries for 554 yards (4.5 average) and two TDs, while catching 54 passes for 398 yards (7.4 average).

Defensively, linebacker T.J. Watt has been a beast. The seven-year veteran from Wisconsin has 18 tackles, including 13 solo, with 8.5 sacks for 59 yards and seven tackles for loss. He also has broken up six passes, intercepted one pass, and forced two fumbles, recovered three fumbles, returning one for a touchdown. In a 17-10 win over Baltimore on Oct. 8, Watt made two solo tackles, had two sacks, broke up two passes and recovered one fumble. See which team to back here.

Why the Titans can cover

Tennessee, which will be without quarterback Ryan Tannehill (ankle), could ride the strength of running back Derrick Henry, who has rushed for 1,000 or more yards in four of the past five seasons, including 2,027 yards in 2020. Last season, Henry rushed for 1,538 yards and 13 touchdowns. So far this season, Henry has carried 120 times for 526 yards (4.4 average) and three touchdowns in seven games. In last Sunday's 28-23 victory over the Atlanta Falcons, he carried 22 times for 101 yards, and caught four passes for 21 yards.

Helping power the defense is defensive end Denico Autry, who has a team-high five sacks for 48 yards. Autry has registered 24 tackles, including 12 solo, with five tackles for loss. He has forced one fumble, batted down two passes and has blocked one kick. He recorded a sack and four tackles in last Sunday's win over Atlanta. See which team to back here.

How to make Steelers vs. Titans picks

White has analyzed this matchup and while we can tell you he's leaning Over the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's sharing what it is, and which side to back, only at SportsLine.

Who wins Titans vs. Steelers on Thursday Night Football, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Titans vs. Steelers spread hits hard, all from the expert who is on an impressive 59-29 run on picks involving Pittsburgh, and find out.