NFL: Chicago Bears at Dallas Cowboys
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Sam Howell's second career start with the Washington Commanders was far from perfect, but he improved his record to 2-0 after engineering multiple fourth-quarter scoring drives. On Sunday, Howell will head to Denver to take on the Broncos, who are coming off a disappointing home loss against the Raiders last week in Sean Payton's Denver coaching debut. The latest Week 2 NFL odds from the SportsLine Consensus list the Broncos as 3.5-point home favorites, but which side should you be backing as you put together your Week 2 NFL bets?

There were eight outright underdogs that won in Week 1 and adding one or two to your NFL parlays in Week 2 can help juice up your return on investment. However, that betting strategy also comes with inherent risk and exactly which underdog to target in your Week 2 NFL predictions can be a challenge. Before you make any Week 2 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 1 of the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of this season.  

The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 2. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 2 NFL picks at SportsLine.

Top Week 2 NFL picks

After simulating every game 10,000 times, the model is high on the Tampa Bay Buccaneers (-2.5) to cover at home against the Chicago Bears. Tampa Bay won as a 4-point underdog in Minnesota during the opening week, while Chicago was demolished as a one-point home favorites against Green Bay.

The Bears suffered a 38-20 loss at the hands of their bitter rivals and familiar issues reared their ugly head, with Justin Fields sacked four times and Chicago only generating five pressures. Chicago also had nine missed tackles, and those defensive issues were a big reason they ranked 32nd in scoring defense and 29th in total defense last season.

Meanwhile, Baker Mayfield played mistake-free football while leading Tampa Bay to a 20-17 victory. If he can continue taking care of the football, the model likes the Buccaneers' chances of forcing the Bears into mistakes. Tampa Bay covers in well over 50% of the model's simulations. See which other NFL parlay picks to make here.

How to make Week 2 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including three underdogs that have a chance to win outright. You can only see the model's NFL Week 2 best bets and parlay at SportsLine

What are the model's top Week 2 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 2 NFL best bets from a model on a 163-113 run on its top-rated picks, and find out.