The Philadelphia Eagles will try to stay undefeated when they host the Pittsburgh Steelers on Sunday. The all-Pennsylvania matchup will mark the Philadelphia debut of defensive end Robert Quinn, who was traded to the Eagles midweek to bolster an already-impressive unit. That defense should present a challenge for rookie Steelers quarterback Kenny Pickett, who has been handed the keys to the offense. A win against Pittsburgh would bring the Eagles to 7-0, and with NFL matchups on tap against struggling teams like the Texans, Commanders, Colts and Packers on tap thereafter, coach Nick Sirianni surely has lofty aspirations. The Eagles are 11-point favorites in the latest Week 8 NFL odds at Caesars Sportsbook. Which Week 8 NFL lines should you target with your Week 8 NFL bets? Before you make any Week 8 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 8 of the 2022 NFL season on an incredible 148-107 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 8. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 8 NFL picks at SportsLine.

Top Week 8 NFL picks

After simulating every game 10,000 times, the model is high on the Buffalo Bills (-11.5) to cover against the Green Bay Packers. The Bills are the only team that has allowed fewer than 100 points so far this season. The Packers will need to outpace the 13.5 points Buffalo has allowed per game if they want to avoid a fourth straight loss.

Green Bay is 16-2 in primetime games since 2019, which bodes well for the Packers in this Sunday Night Football matchup. But getting a 17th W will be a tall task considering that the Packers have been stuck in neutral for weeks and the Bills' dominance on both sides of the ball. Add in that this game will be played in Buffalo, and Green Bay will be hard-pressed to cover. That is one reason the Bills are covering the spread in over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 8 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that will win outright. You can only see the model's NFL Week 8 best bets and parlay at SportsLine

What are the model's top Week 8 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 8 NFL best bets from a model on a 148-107 run on its top-rated picks, and find out.