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The Sweet 16 round of the 2024 NCAA Tournament gets underway on Thursday when the No. 6 seed Clemson Tigers take on the No. 2 seed Arizona Wildcats. Arizona advanced to the Sweet 16 with wins over Long Beach State and Dayton in the first two rounds. Meanwhile, Clemson is coming off an upset victory over the Baylor Bears in the second round of the NCAA Tournament 2024. 

Tipoff from the Crypto.com Arena in Los Angeles is set for 7:09 p.m. ET. The Wildcats are 7-point favorites in the latest Clemson vs. Arizona odds from SportsLine consensus, while the over/under for total points scored is 152. Before entering any Arizona vs. Clemson picks, make sure you see the college basketball predictions and betting advice from the SportsLine Projection Model

The model simulates every Division I college basketball game 10,000 times. It enters the Sweet 16 round of the 2024 NCAA tournament on a 152-109 roll on all top-rated college basketball picks dating back to last season, returning more than $1,800 for $100 players. It also has a strong 32-21 (+890) record on top-rated spread picks this season, and it called 13 Sweet 16 teams this year. Anyone following has seen huge returns.

Now, the model has set its sights on Arizona vs. Clemson and revealed its March Madness picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and trends for Clemson vs. Arizona:

  • Arizona vs. Clemson spread: Arizona -7
  • Arizona vs. Clemson over/under: 152 points
  • Arizona vs. Clemson money line: Arizona -306, Clemson +245
  • AZ: 20-12-1 ATS this season as the favorite
  • CLEM: 8-1 ATS this season as the underdog
  • Arizona vs. Clemson picks: See picks at SportsLine

Why Arizona can cover

Senior guard Pelle Larsson can make an impact off the ball or as a shot creator. Larsson has good vision to get his teammates involved but also has a knockdown perimeter jumper. The Sweden native averages 12.9 points, 4.1 rebounds, and 3.7 assists per game. In his last outing, Larsson tallied 13 points, seven rebounds, and six assists.

Senior forward Keshad Johnson is a downhill scoring threat. Johnson glides to the rack and plays top-notch defense on the other end. The California native averages 11.7 points, 5.7 rebounds, and one steal per contest. In Arizona's win over Dayton, Johnson totaled 13 points, seven rebounds, and two steals. See which team to pick here.

Why Clemson can cover

Junior forward Ian Schieffelin is active down low. Schieffelin always seems to be in the right spot and is relentlessly fighting on the boards. He averages a team-high 9.5 rebounds to go along with 9.8 points per game. He's knocking down 57.3% of his field goals this season. Schieffelin had 16 points and 12 boards in Clemson's first-round win over New Mexico

Senior guard Joseph Girard III gives the Tigers a perimeter asset. Girard III isn't the most athletic player on the floor but he is an instinctive playmaker. The New York native averages 15.3 points and 2.9 assists while knocking down 41.4% of his 3-pointers. On Sunday against Baylor, he finished with 13 points and three assists. See which team to pick here

How to make Clemson vs. Arizona picks

SportsLine's model is leaning Over on the total, projecting 156 combined points. The model also says one side of the spread hits in 60% of simulations. You can only see the model's picks at SportsLine

So who wins Arizona vs. Clemson, and which side of the spread hits 60% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model on a 32-21 roll on top-ranked college basketball spread picks, and find out.