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The No. 5 Kansas State Wildcats will try to remain in first place atop the Big 12 standings when they face the No. 12 Iowa State Cyclones on Tuesday night. The Wildcats have won 11 of their last 12 games, including wins over then-No. 2 Kansas and Texas Tech last week. Iowa State has dropped two of its last three games, falling to Oklahoma State in a 61-59 thriller on Saturday. 

Tipoff is set for 9 p.m. ET. The Cyclones are favored by 6 points in the latest Iowa State vs. Kansas State odds from Caesars Sportsbook, while the over/under is set at 134.5. Before entering any Kansas State vs. Iowa State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 12 of the season 45-26 on all top-rated college basketball picks, returning more than $1,100 for $100 players. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Kansas State. You can head to SportsLine to see its picks. Here are several college basketball odds for Iowa State vs. Kansas State:

  • Iowa State vs. Kansas State spread: Iowa State -6
  • Iowa State vs. Kansas State over/under: 134 points
  • Iowa State vs. Kansas State money line: Iowa State -225, Kansas State +185
  • Iowa State vs. Kansas State picks: See picks here

Why Iowa State can cover

Iowa State continues to be one of the best home teams in college basketball, having won all 10 of its games at James H. Hilton Coliseum coming into this matchup. The Cyclones have only lost two games in Big 12 play, with both of those setbacks coming by two points on the road. They have covered the spread in six of their last seven games, so they have been undervalued in conference play. 

Kansas State is in a letdown spot after picking up two huge wins over Kansas and Texas Tech, making this a difficult scheduling spot. The Wildcats lost to TCU by 14 points on the road in their last road game, trailing 43-29 at halftime before cruising in the second half. Senior guard Jaren Holmes leads a balanced Iowa State lineup with 12.9 points and 3.3 assists per game, while Gabe Kalscheur (12.8) and Caleb Grill (10.3) are both scoring in double figures as well. 

Why Kansas State can cover

Iowa State is going to have a tough time recovering from its loss to Oklahoma State on Saturday, as it led by 16 points before blowing the lead in a 61-59 final. The Cyclones were sitting atop the conference standings prior to that setback. Kansas State avoided an upset loss in its game on Saturday, using a 31-13 run down the stretch to pick up a win against Texas Tech and jump to the top of the standings. 

Markquis Nowell led Kansas State with a game-high 23 points, while Keyontae Johnson (15) and Ismael Massoud (12) also reached double digits. Johnson has re-established himself as one of the best players in college basketball, averaging 18.5 points and 7.4 rebounds per game. The Wildcats have covered the spread in six of their last seven games and have won four of the last five meetings between these teams. 

How to make Iowa State vs. Kansas State picks

The model has simulated Kansas State vs. Iowa State 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Iowa State vs. Kansas State? And which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is 45-26 on its top-rated college basketball picks this season, and find out.