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The Oklahoma State Cowboys and the TCU Horned Frogs will face off Wednesday in a Big 12 battle at 9 p.m. ET at Ed & Rae Schollmaier Arena. TCU is 9-7 overall and 4-4 at home, while Oklahoma State is 11-4 overall and 6-1 on the road. The Cowboys are 5-0-1 against the spread in their last six road games. The Horned Frogs are 7-3 against the spread in their last 10 games as an underdog.

The Cowboys are favored by 4.5-points in the latest TCU vs. Oklahoma State odds from William Hill Sportsbook, and the over-under is set at 141. Before entering any Oklahoma State vs. TCU picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on TCU vs. Oklahoma State. You can head to SportsLine to see its picks. Here are several college basketball odds for TCU vs. Oklahoma State:

  • TCU vs. Oklahoma State spread: Oklahoma State -4.5
  • TCU vs. Oklahoma State over-under: 141 points
  • TCU vs. Oklahoma State money line: Oklahoma State -200, TCU +170

What you need to know about TCU

The Horned Frogs have lost five straight games, including a 102-98 overtime loss at Missouri on Saturday. TCU got a strong performance in the loss from Mike Miles, who had 28 points, five rebounds and five assists. RJ Nembhard leads TCU in scoring with 16.6 points, while Kevin Samuel delivers 8.8 rebounds per game.

Despite losing five straight, TCU will enter Wednesday's contest confident it can pull off the upset. That's because TCU is 5-1 in its last six games at home against the Cowboys.

What you need to know about Oklahoma State

The Cowboys won their second straight game, downing Arkansas 81-77 on Saturday. Oklahoma State relied on the efforts of forward Kalib Boone, who posted a double-double with 16 points and 12 rebounds in addition to three blocks, and guard Cade Cunningham, who had 21 points, seven rebounds and five assists. Cunningham leads Oklahoma State with 18.1 points per game, while Isaac Likekele delivers 7.5 rebounds and 4.0 assists per game.

The Cowboys have won seven of their last eight road games, and they're 4-1 against the spread in their last five games overall. In addition, Oklahoma State is 4-2 ATS in its last six meetings against the Horned Frogs. 

How to make Oklahoma State vs. TCU picks

The model has simulated TCU vs. Oklahoma State 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins TCU vs. Oklahoma State? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to find out which side of the Oklahoma State vs. TCU spread you need to jump on Wednesday, all from the model that has crushed its college basketball picks, and find out.