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The Ole Miss Rebels and the Alabama Crimson Tide are set to square off in an SEC matchup at 8:30 p.m. ET Wednesday at The Pavilion at Ole Miss. The Rebels are 12-11 overall and 10-4 at home, while Bama is 14-9 overall and 1-5 on the road. It's a rivalry that Alabama has dominated of late, with the Crimson Tide winning and covering in six of the last seven head-to-head matchups.

However, Alabama has struggled against the spread this season with an 8-15 mark while Ole Miss is 11-12 against the number. The Crimson Tide are favored by 5.5 points in the latest Ole Miss vs. Alabama odds from Caesars Sportsbook and the over-under is set at 143.5. Before entering any Alabama vs. Ole Miss picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ole Miss vs. Alabama. You can head to SportsLine to see its picks. Here are several college basketball odds for Alabama vs. Ole Miss:

  • Ole Miss vs. Alabama spread: Ole Miss +5.5
  • Ole Miss vs. Alabama over-under: 143.5 points
Featured Game | Ole Miss Rebels vs. Alabama Crimson Tide

What you need to know about Ole Miss

The Rebels were within striking distance but couldn't close the gap this past Saturday as they fell 62-57 to the Florida Gators. One thing holding Ole Miss back was the mediocre play of guard Jarkel Joiner, who did not have his best game. He played for 40 minutes but put up just seven points on 3-for-10 shooting.

It was Joiner's first game in just under a month after he suffered a back injury in early January against archrival Mississippi State. The former Cal State Bakersfield transfer is leading the team in scoring this season (13.1 ppg) and second-leading scorer Daeshun Ruffin (12.6 ppg) is out for the rest of the season with a knee injury, so Ole Miss will need Joiner to settle in during his second game back from injury.

What you need to know about Alabama

Meanwhile, the game between Bama and the Kentucky Wildcats this past Saturday was not particularly close, with Bama falling 66-55. Center Charles Bediako put forth a good effort for the losing side as he had 12 points along with eight boards. The true freshman also had a block in the game and has had nine multi-block games this season. His ability to alter the game at that end of the floor could be critical in a matchup against Nysier Brooks.

Offensively, the Crimson Tide shot just 28.1 percent from the floor and went just 3-for-30 from the 3-point line in the loss to Kentucky. Alabama has now lost three of its last four games and Nate Oats' squad will need to stem the tide if it expects to stay in the running for an at-large bid in the 2022 NCAA Tournament.

How to make Alabama vs. Ole Miss picks

The model has simulated Ole Miss vs. Alabama 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Ole Miss vs. Alabama? And which side of the spread hits 60 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.