The Clemson Tigers will try to bounce back from their first loss of the season when they face the Louisville Cardinals on Saturday afternoon. Clemson won its first eight games prior to losing at Notre Dame last week. Meanwhile, Louisville is riding a four-game winning streak following its 34-10 win against James Madison.
Kickoff is set for 3:30 p.m. ET. The Tigers are favored by 7 points in the latest Clemson vs. Louisville odds from Caesars Sportsbook, while the over/under is set at 52. Before entering any Louisville vs. Clemson picks, you'll want to see the college football predictions from the proven computer model at SportsLine.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Clemson vs. Louisville. You can head to SportsLine to see its picks. Here are several college football odds for Clemson vs. Louisville:
- Clemson vs. Louisville spread: Clemson -7
- Clemson vs. Louisville over/under: 52 points
- Clemson vs. Louisville money line: Clemson -278, Louisville +222
- Clemson vs. Louisville picks: See picks here
Why Clemson can cover
Clemson is coming off a road loss to Notre Dame, but it has still picked up wins over three ranked opponents this season. The Tigers cannot afford another loss if they want to remain in contention for a spot in the College Football Playoff, so they will be motivated for this game. They are riding a 38-game home winning streak and have never lost to Louisville in seven previous meetings.
The Tigers have gone 14-0 in their last 14 games following a loss and still have one of the best defenses in the country. Junior quarterback DJ Uiagalelei has thrown for nearly 2,000 yards and 18 touchdowns this season, while also rushing for 373 yards and four scores. Running back Will Shipley is averaging 5.9 yards per carry and has scored 11 times.
Why Louisville can cover
Louisville got off to a slow start this season, but it has rattled off four consecutive wins to become bowl eligible. The Cardinals have won all four of those games by double digits, including a 48-21 win over then-No. 10 Wake Forest two weeks ago. They racked up 244 rushing yards against James Madison last week, despite the Dukes entering that game with the top run defense in the country.
Running back Tiyon Evans had 10 carries for 126 yards and a touchdown, while Jawhar Jordan added 17 attempts for 117 yards. Quarterback Malik Cunningham, who is one of the most dynamic players in college football, has amassed more than 2,000 total yards and 19 touchdowns this season.
How to make Clemson vs. Louisville picks
The model has simulated Louisville vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.
So who wins Clemson vs. Louisville? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the Louisville vs. Clemson spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.
